RT Journal Article T1 Mediators in Psychological Treatments for Anxiety and Depression in Adolescents and Young People: A Protocol of a Systematic Review. A1 Conejo-Cerón, Sonia A1 Taubner, Svenja A1 Heinonen, Erkki A1 Adler, Asta A1 Barkauskiene, Rasa A1 Di Giacomo, Dina A1 Ioannou, Yianna A1 Mestre, Jose M A1 Henriques, Margarida Rangel A1 Mota, Catarina Pinheiro A1 Protić, Sonja A1 Raleva, Marija A1 Vieira, Filipa Mucha A1 Røssberg, Jan Ivar A1 Sales, Célia M D A1 Saliba, Andrea A1 Schmidt, Stefanie J A1 Perdih, Tjaša Stepišnik A1 Ulberg, Randi A1 Volkert, Jana A1 Moreno-Peral, Patricia K1 adolescence K1 anxiety K1 depression K1 mediator K1 psychotherapy K1 systematic review K1 young adult AB Anxiety and depressive disorders are a significant problem that starts in childhood or adolescence and should be addressed early to avoid chronic mental conditions. There is strong evidence to demonstrate that psychological treatments are effective for these disorders, however, little is known on mediators and mechanisms of change of psychological treatment in adolescents and young adults. Understanding the pathways through which psychological treatments operate will facilitate more effective treatments. We aim to conduct a systematic review, exploring the available evidence on mediators of psychological treatments for anxiety and depression in adolescents and young adults. A systematic search has been performed on PubMed and PsycINFO databases to identify studies from inception to 23rd February 2020. Eligible studies include randomized controlled trials and trials (quasi-experimental) designs that have enrolled adolescents and young adults presenting with depression and/or anxiety and that have examined mediators of psychological treatments. A group of 20 reviewers from the COST-Action TREATme (CA16102) divided into 10 pairs independently screen studies for inclusion, extract information from the included studies, and assess the methodological quality of the included studies and the requirements for mediators. The methodological quality will be assessed by The Mixed Methods Appraisal Tool. Extracted data from the included studies will be collected and presented using a narrative approach. This systematic review will summarize and provide a comprehensive overview of the current evidence on mediators of psychological treatments for anxiety and depression for adolescents and young adults. Results will allow the identification of strategies to optimize intervention to enhance clinical outcomes. Ethics approval is not required. Findings from this systematic review will be published in a peer-reviewed journal and disseminated at conferences and meetings. PROSPERO registration number: CRD42021234641. SN 1664-1078 YR 2021 FD 2021-07-21 LK http://hdl.handle.net/10668/18336 UL http://hdl.handle.net/10668/18336 LA en DS RISalud RD Apr 18, 2025