RT Journal Article
T1 Congenital infection of SARS-CoV-2 in live-born neonates: a population-based descriptive study.
A1 Garcia-Ruiz, Itziar
A1 Sulleiro, Elena
A1 Serrano, Berta
A1 Fernandez-Buhigas, Irene
A1 Rodriguez-Gomez, Leire
A1 Sanchez-Nieves Fernandez, David
A1 Anton-Pagarolas, Andrés
A1 Esperalba-Esquerra, Juliana
A1 Frick, Marie Antoinette
A1 Camba, Fatima
A1 Navarro-Jimenez, Alexandra
A1 Fernandez-Hidalgo, Nuria
A1 Maiz, Nerea
A1 Carreras, Elena
A1 Suy, Anna
A1 GESTACOVID Collaborative Group, 
K1 Congenital infection
K1 Coronavirus disease 2019
K1 Mother-to-child transmission
K1 Pregnancy
K1 Severe acute respiratory syndrome coronavirus 2
AB To evaluate the evidence of mother-to-child transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This is a descriptive, multicentre, observational study in nine tertiary care hospitals throughout Spain. The study population was women with coronavirus disease 2019 during pregnancy. Mother-to-child transmission was defined as positive real-time RT-PCR of SARS-CoV-2 in amniotic fluid, cord blood, placenta or neonatal nasopharyngeal swabs taken immediately after birth. We included 43 women with singleton pregnancies and one with a twin pregnancy, as a result we obtained 45 samples of placenta, amniotic fluid and umbilical cord blood. The median gestational age at diagnosis was 34.7 weeks (range 14-41.3 weeks). The median interval between positive RT-PCR and delivery was 21.5 days (range 0-141 days). Fourteen women (31.8%, 95% CI 18.6%-47.6%) were positive at the time of delivery. There was one singleton pregnancy with SARS-CoV-2 RT-PCR positive in the placenta, amniotic fluid and umbilical cord blood (2.2%, 95% CI 0.1%-11.8%). Nasopharyngeal aspiration was performed on 38 neonates at birth, all of which were negative (0%, 95% CI 0%-9.3%). In 11 neonates the nasopharyngeal aspiration was repeated at 24-48 hours, and one returned positive (9.1%, 95% CI 0.2%-41.3%). The presence of SARS-CoV-2 in placenta, amniotic fluid and cord blood shows that mother-to-child transmission is possible but uncommon.
YR 2021
FD 2021-06-19
LK https://hdl.handle.net/10668/25970
UL https://hdl.handle.net/10668/25970
LA en
DS RISalud
RD Apr 17, 2025