RT Journal Article T1 Extrahypothalamic Control of Energy Balance and Its Connection with Reproduction: Roles of the Amygdala A1 Pineda, Rafael A1 Torres, Encarnacion A1 Tena-Sempere, Manuel K1 Metabolism K1 Amygdala K1 Estrogens K1 Neuropeptides K1 Kisspeptins K1 Food intake K1 Energy balance K1 Body weight K1 Obesity K1 Metabolismo K1 Amígdala del cerebelo K1 Estrógenos K1 Neuropéptidos K1 Kisspeptinas K1 Ingestión de alimentos K1 Peso corporal K1 Obesidad AB Body energy and metabolic homeostasis are exquisitely controlled by multiple, often overlapping regulatory mechanisms, which permit the tight adjustment between fuel reserves, internal needs, and environmental (e.g., nutritional) conditions. As such, this function is sensitive to and closely connected with other relevant bodily systems, including reproduction and gonadal function. The aim of this mini-review article is to summarize the most salient experimental data supporting a role of the amygdala as a key brain region for emotional learning and behavior, including reward processing, in the physiological control of feeding and energy balance. In particular, a major focus will be placed on the putative interplay between reproductive signals and amygdala pathways, as it pertains to the control of metabolism, as complementary, extrahypothalamic circuit for the integral control of energy balance and gonadal function. PB MDPI YR 2021 FD 2021-12-03 LK http://hdl.handle.net/10668/4441 UL http://hdl.handle.net/10668/4441 LA en NO Pineda R, Torres E, Tena-Sempere M. Extrahypothalamic Control of Energy Balance and Its Connection with Reproduction: Roles of the Amygdala. Metabolites. 2021 Dec 3;11(12):837 DS RISalud RD Apr 18, 2025