%0 Journal Article
%A Nguyen, Dung
%A Simmonds, Peter
%A Steenhuis, Maurice
%A Wouters, Elise
%A Desmecht, Daniel
%A Garigliany, Mutien
%A Romano, Marta
%A Barbezange, Cyril
%A Maes, Piet
%A Van Holm, Bram
%A Mendoza, Joaquín
%A Oyonarte, Salvador
%A Fomsgaard, Anders
%A Lassaunière, Ria
%A Zusinaite, Eva
%A Resman Rus, Katarina
%A Avšič-Županc, Tatjana
%A Reimerink, Johan Hj
%A Brouwer, Fiona
%A Hoogerwerf, Marieke
%A Reusken, Chantal Bem
%A Grodeland, Gunnveig
%A Le Cam, Sophie
%A Gallian, Pierre
%A Amroun, Abdennour
%A Brisbarre, Nadège
%A Martinaud, Christophe
%A Leparc Goffart, Isabelle
%A Schrezenmeier, Hubert
%A Feys, Hendrik B
%A van der Schoot, C Ellen
%A Harvala, Heli
%T SARS-CoV-2 neutralising antibody testing in Europe: towards harmonisation of neutralising antibody titres for better use of convalescent plasma and comparability of trial data.
%D 2021
%U http://hdl.handle.net/10668/18180
%X We compared the performance of SARS-CoV-2 neutralising antibody testing between 12 European laboratories involved in convalescent plasma trials. Raw titres differed almost 100-fold differences between laboratories when blind-testing 15 plasma samples. Calibration of titres in relation to the reference reagent and standard curve obtained by testing a dilution series reduced the inter-laboratory variability ca 10-fold. The harmonisation of neutralising antibody quantification is a vital step towards determining the protective and therapeutic levels of neutralising antibodies.
%K Europe
%K SARS-CoV-2
%K convalescent plasma
%K neutralising antibodies
%K standardisation, COVID-19
%~