RT Journal Article
T1 Gut microbiota and voluntary alcohol consumption.
A1 Segovia-Rodriguez, L
A1 Echeverry-Alzate, V
A1 Rincon-Perez, I
A1 Calleja-Conde, J
A1 Buhler, K M
A1 Gine, E
A1 Albert, J
A1 Hinojosa, J A
A1 Huertas, E
A1 Gomez-Gallego, F
A1 Bressa, C
A1 Rodriguez-de-Fonseca, F
A1 Lopez-Moreno, J A
K1 Alcohol Drinking
K1 Animals
K1 Anti-Bacterial Agents
K1 Bacteria
AB Alcohol is part of the usual diet of millions of individuals worldwide. However, not all individuals who drink alcohol experience the same effects, nor will everyone develop an alcohol use disorder. Here we propose that the intestinal microbiota (IMB) helps explain the different consumption patterns of alcohol among individuals. 507 humans participated in this study and alcohol consumption and IMB composition were analyzed. On the other hand, in 80 adult male Wistar rats, behavioral tests, alcohol intoxication, fecal transplantation, administration of antibiotics and collection of fecal samples were performed. For identification and relative quantification of bacterial taxa was used the bacterial 16 S ribosomal RNA gene. In humans, we found that heavy episodic drinking is associated with a specific stool type phenotype (type 1, according to Bristol Stool Scale; p <0.05) and with an increase in the abundance of Actinobacteria (p <0.05). Next, using rats, we demonstrate that the transfer of IMB from alcohol-intoxicated animals causes an increase in voluntary alcohol consumption in transplant-recipient animals (p < 0.001). The relative quantification data indicate that the genus Porphyromonas could be associated with the effect on voluntary alcohol consumption. We also show that gut microbiota depletion by antibiotics administration causes a reduction in alcohol consumption (p <0.001) and altered the relative abundance of relevant phyla such as Firmicutes, Bacteroidetes or Cyanobacteria (p < 0.05), among others. Benjamini–Hochberg false discovery rate (FDR) correction was performed for multiple comparisons. These studies reveal some of the consequences of alcohol on the IMB and provide evidence that manipulation of IMB may alter voluntary alcohol consumption.
PB Nature Publishing Group
YR 2022
FD 2022-04-07
LK http://hdl.handle.net/10668/19513
UL http://hdl.handle.net/10668/19513
LA en
NO Segovia-Rodríguez L, Echeverry-Alzate V, Rincón-Pérez I, Calleja-Conde J, Bühler KM, Giné E, et al. Gut microbiota and voluntary alcohol consumption. Transl Psychiatry. 2022 Apr 7;12(1):146
NO This work was supported by National Plan on Drug abuse, Ministerio de Sanidad of Spain (grant PNSD2018-050 to JALM), the Fondo de Investigación Sanitaria (Red de Trastornos Adictivos, FEDER, RD16/0017/0008 to JALM, and RD12/0028/001 to FRDF), as well as by the Ministerio de Economía, Industrias y Competitividad (PSI201784922-R SI1), the Comunidad de Madrid (PJI/2019-00061) and the Instituto de Salud Carlos III (“Sara Borrell” research contract CD17/00125 to VEA).
DS RISalud
RD Apr 15, 2025