TY - JOUR AU - Fuentes-Fayos, Antonio C AU - Vazquez-Borrego, Mari C AU - Jimenez-Vacas, Juan M AU - Bejarano, Leire AU - Pedraza-Arevalo, Sergio AU - L-Lopez, Fernando AU - Blanco-Acevedo, Cristobal AU - Sanchez-Sanchez, Rafael AU - Reyes, Oscar AU - Ventura, Sebastian AU - Solivera, Juan AU - Breunig, Joshua J AU - Blasco, Maria A AU - Gahete, Manuel D AU - Castaño, Justo P AU - Luque, Raul M PY - 2020 DO - 10.1093/brain/awaa273 UR - http://hdl.handle.net/10668/16534 T2 - Brain : a journal of neurology AB - Glioblastomas remain the deadliest brain tumour, with a dismal ∼12-16-month survival from diagnosis. Therefore, identification of new diagnostic, prognostic and therapeutic tools to tackle glioblastomas is urgently needed. Emerging evidence indicates... LA - en PB - Oxford University Press KW - PDGFRB pathway KW - SRSF3 KW - Antitumour therapy KW - Glioblastoma KW - Splicing machinery KW - Alternative splicing KW - Apoptosis KW - Biomarkers, tumor KW - Brain neoplasms KW - Cell movement KW - Cell proliferation KW - Gene expression regulation, neoplastic KW - Gene silencing KW - Glioblastoma KW - Humans KW - Neoplasm invasiveness KW - Receptor, platelet-derived growth factor beta KW - Serine-arginine splicing factors KW - Signal transduction KW - Survival analysis KW - Xenograft model antitumor assays TI - Splicing machinery dysregulation drives glioblastoma development/aggressiveness: oncogenic role of SRSF3. TY - research article VL - 143 ER -