RT Journal Article
T1 Hyperventilation Therapy for Control of Posttraumatic Intracranial Hypertension.
A1 Godoy, Daniel Agustín
A1 Seifi, Ali
A1 Garza, David
A1 Lubillo-Montenegro, Santiago
A1 Murillo-Cabezas, Francisco
K1 cerebral hypoxia
K1 cerebral ischemia
K1 hyperventilation
K1 hypocapnia
K1 intracranial hypertension
K1 intracranial pressure
K1 severe traumatic brain injury
AB During traumatic brain injury, intracranial hypertension (ICH) can become a life-threatening condition if it is not managed quickly and adequately. Physicians use therapeutic hyperventilation to reduce elevated intracranial pressure (ICP) by manipulating autoregulatory functions connected to cerebrovascular CO2 reactivity. Inducing hypocapnia via hyperventilation reduces the partial pressure of arterial carbon dioxide (PaCO2), which incites vasoconstriction in the cerebral resistance arterioles. This constriction decrease cerebral blood flow, which reduces cerebral blood volume and, ultimately, decreases the patient's ICP. The effects of therapeutic hyperventilation (HV) are transient, but the risks accompanying these changes in cerebral and systemic physiology must be carefully considered before the treatment can be deemed advisable. The most prominent criticism of this approach is the cited possibility of developing cerebral ischemia and tissue hypoxia. While it is true that certain measures, such as cerebral oxygenation monitoring, are needed to mitigate these dangerous conditions, using available evidence of potential poor outcomes associated with HV as justification to dismiss the implementation of therapeutic HV is debatable and remains a controversial subject among physicians. This review highlights various issues surrounding the use of HV as a means of controlling posttraumatic ICH, including indications for treatment, potential risks, and benefits, and a discussion of what techniques can be implemented to avoid adverse complications.
SN 1664-2295
YR 2017
FD 2017-07-17
LK https://hdl.handle.net/10668/27192
UL https://hdl.handle.net/10668/27192
LA en
DS RISalud
RD Apr 11, 2025