RT Journal Article T1 European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). A1 Egea, Javier A1 Fabregat, Isabel A1 Frapart, Yves M A1 Ghezzi, Pietro A1 Görlach, Agnes A1 Kietzmann, Thomas A1 Kubaichuk, Kateryna A1 Knaus, Ulla G A1 Lopez, Manuela G A1 Olaso-Gonzalez, Gloria A1 Petry, Andreas A1 Schulz, Rainer A1 Vina, Jose A1 Winyard, Paul A1 Abbas, Kahina A1 Ademowo, Opeyemi S A1 Afonso, Catarina B A1 Andreadou, Ioanna A1 Antelmann, Haike A1 Antunes, Fernando A1 Aslan, Mutay A1 Bachschmid, Markus M A1 Barbosa, Rui M A1 Belousov, Vsevolod A1 Berndt, Carsten A1 Bernlohr, David A1 Bertrán, Esther A1 Bindoli, Alberto A1 Bottari, Serge P A1 Brito, Paula M A1 Carrara, Guia A1 Casas, Ana I A1 Chatzi, Afroditi A1 Chondrogianni, Niki A1 Conrad, Marcus A1 Cooke, Marcus S A1 Costa, João G A1 Cuadrado, Antonio A1 My-Chan Dang, Pham A1 De Smet, Barbara A1 Debelec-Butuner, Bilge A1 Dias, Irundika H K A1 Dunn, Joe Dan A1 Edson, Amanda J A1 El Assar, Mariam A1 El-Benna, Jamel A1 Ferdinandy, Péter A1 Fernandes, Ana S A1 Fladmark, Kari E A1 Förstermann, Ulrich A1 Giniatullin, Rashid A1 Giricz, Zoltán A1 Görbe, Anikó A1 Griffiths, Helen A1 Hampl, Vaclav A1 Hanf, Alina A1 Herget, Jan A1 Hernansanz-Agustín, Pablo A1 Hillion, Melanie A1 Huang, Jingjing A1 Ilikay, Serap A1 Jansen-Dürr, Pidder A1 Jaquet, Vincent A1 Joles, Jaap A A1 Kalyanaraman, Balaraman A1 Kaminskyy, Danylo A1 Karbaschi, Mahsa A1 Kleanthous, Marina A1 Klotz, Lars-Oliver A1 Korac, Bato A1 Korkmaz, Kemal Sami A1 Koziel, Rafal A1 Kračun, Damir A1 Krause, Karl-Heinz A1 Křen, Vladimír A1 Krieg, Thomas A1 Laranjinha, João A1 Lazou, Antigone A1 Li, Huige A1 Martínez-Ruiz, Antonio A1 Matsui, Reiko A1 McBean, Gethin J A1 Meredith, Stuart P A1 Messens, Joris A1 Miguel, Verónica A1 Mikhed, Yuliya A1 Milisav, Irina A1 Milković, Lidija A1 Miranda-Vizuete, Antonio A1 Mojović, Miloš A1 Monsalve, María A1 Mouthuy, Pierre-Alexis A1 Mulvey, John A1 Münzel, Thomas A1 Muzykantov, Vladimir A1 Nguyen, Isabel T N A1 Oelze, Matthias A1 Oliveira, Nuno G A1 Palmeira, Carlos M A1 Papaevgeniou, Nikoletta A1 Pavićević, Aleksandra A1 Pedre, Brandán A1 Peyrot, Fabienne A1 Phylactides, Marios A1 Pircalabioru, Gratiela G A1 Pitt, Andrew R A1 Poulsen, Henrik E A1 Prieto, Ignacio A1 Rigobello, Maria Pia A1 Robledinos-Antón, Natalia A1 Rodríguez-Mañas, Leocadio A1 Rolo, Anabela P A1 Rousset, Francis A1 Ruskovska, Tatjana A1 Saraiva, Nuno A1 Sasson, Shlomo A1 Schröder, Katrin A1 Semen, Khrystyna A1 Seredenina, Tamara A1 Shakirzyanova, Anastasia A1 Smith, Geoffrey L A1 Soldati, Thierry A1 Sousa, Bebiana C A1 Spickett, Corinne M A1 Stancic, Ana A1 Stasia, Marie José A1 Steinbrenner, Holger A1 Stepanić, Višnja A1 Steven, Sebastian A1 Tokatlidis, Kostas A1 Tuncay, Erkan A1 Turan, Belma A1 Ursini, Fulvio A1 Vacek, Jan A1 Vajnerova, Olga A1 Valentová, Kateřina A1 Van Breusegem, Frank A1 Varisli, Lokman A1 Veal, Elizabeth A A1 Yalçın, A Suha A1 Yelisyeyeva, Olha A1 Žarković, Neven A1 Zatloukalová, Martina A1 Zielonka, Jacek A1 Touyz, Rhian M A1 Papapetropoulos, Andreas A1 Grune, Tilman A1 Lamas, Santiago A1 Schmidt, Harald H H W A1 Di Lisa, Fabio A1 Daiber, Andreas K1 Antioxidants K1 Oxidative stress K1 Reactive nitrogen species K1 Reactive oxygen species K1 Redox signaling K1 Redox therapeutics AB The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed. YR 2017 FD 2017-05-18 LK http://hdl.handle.net/10668/11268 UL http://hdl.handle.net/10668/11268 LA en DS RISalud RD Apr 6, 2025