TY  - JOUR
AU  - Garrido, Maria Antonia
AU  - Perea, Francisco
AU  - Vilchez, Jose Ramon
AU  - Rodríguez, Teresa
AU  - Anderson, Per
AU  - Garrido, Federico
AU  - Ruiz-Cabello, Francisco
AU  - Aptsiauri, Natalia
PY  - 2021
DO  - 10.3390/cancers13205046
UR  - http://hdl.handle.net/10668/4239
T2  - Cancers
AB  - Total or partial loss of HLA class I antigens reduce the recognition of specific tumor peptides by cytotoxic T lymphocytes favoring cancer immune escape during natural tumor evolution. These alterations can be caused by genomic defects, such as loss...
LA  - en
PB  - MDPI
KW  - Cancer immune escape
KW  - HLA class I
KW  - Copy-neutral loss of heterozygosity (CN-LOH)
KW  - Antigen presentation
KW  - Beta2-microglobulin
KW  - Cytotoxic T-cells
KW  - Cancer immunotherapy
KW  - Escape del tumor
KW  - Genes MHC clase I
KW  - Pérdida de heterocigosidad
KW  - Presentación de antígeno
KW  - Microglobulina beta-2
KW  - Linfocitos T citotóxicos
KW  - Inmunoterapia
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Major Histocompatibility Complex::Genes, MHC Class I
KW  - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Chromosome Aberrations::Chromosome Duplication
KW  - Medical Subject Headings::Anatomy::Cells::Cellular Structures::Chromosomes::Chromosomes, Mammalian::Chromosomes, Human::Chromosomes, Human, 6-12 and X::Chromosomes, Human, Pair 6
KW  - Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Cytokine-Induced Killer Cells::T-Lymphocytes, Cytotoxic
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation::Allelic Imbalance::Loss of Heterozygosity
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class I
KW  - Medical Subject Headings::Diseases::Neoplasms
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy
KW  - Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genomics
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Globulins::Serum Globulins::Beta-Globulins::beta 2-Microglobulin
KW  - Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Tumor Escape
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation::Allelic Imbalance::Loss of Heterozygosity
KW  - Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes::T-Lymphocyte Subsets::T-Lymphocytes, Cytotoxic
TI  - Copy Neutral LOH Affecting the Entire Chromosome 6 Is a Frequent Mechanism of HLA Class I Alterations in Cancer
TY  - research article
ER  -