RT Journal Article
T1 Laparoscopic surgery versus radiofrequency ablation for the treatment of single hepatocellular carcinoma ≤3 cm in the elderly: a propensity score matching analysis.
A1 Conticchio, Maria
A1 Delvecchio, Antonella
A1 Ratti, Francesca
A1 Gelli, Maximiliano
A1 Anelli, Ferdinando M
A1 Laurent, Alexis
A1 Vitali, Giulio C
A1 Magistri, Paolo
A1 Assirati, Giacomo
A1 Felli, Emanuele
A1 Wakabayashi, Taiga
A1 Pessaux, Patrick
A1 Piardi, Tullio
A1 Di Benedetto, Fabrizio
A1 de'Angelis, Nicola
A1 Javier Briceno, Delgado F
A1 Rampoldi, Antonio G
A1 Adam, René
A1 Cherqui, Daniel
A1 Aldrighetti, Luca
A1 Memeo, Riccardo
AB Laparoscopic liver resection (LLR) and radiofrequency ablation (RFA) represented potential treatments for patients with a single hepatocellular carcinoma (HCC) smaller than 3 cm. As the aging population soared, our study aimed to examine the advantage/drawback balance for these treatments, which should be reassessed in elderly patients. A multicentric retrospective study compared 184 elderly patients (aged >70 years) (86 patients underwent LLR and 98 had RFA) with single ≤3 cm HCC, observed from January 2009 to January 2019. After propensity score matching (PSM), the estimated 1- and 3-year overall survival rates were 96.5 and 87.9% for the LLR group, and 94.6 and 68.1% for the RFA group (p = 0.001) respectively. The estimated 1- and 3-year disease-free survival rates were 92.5 and 67.4% for the LLR group, and 68.5 and 36.9% for the RFA group (p = 0.001). Patients with HCC of anterolateral segments were more often treated with laparoscopic resection (47 vs. 36, p = 0.04). The median operative time in the resection group was 205 min and 25 min in the RFA group (p = 0.01). Length of hospital stay was 5 days in the resection group and 3 days in the RFA group (p = 0.03). Despite a longer length of hospital stay and operative time, LLR guarantees a comparable postoperative course and a better overall and disease-free survival in elderly patients with single HCC (≤3 cm), located in anterolateral segments.
YR 2021
FD 2021-06-08
LK http://hdl.handle.net/10668/22255
UL http://hdl.handle.net/10668/22255
LA en
DS RISalud
RD Apr 5, 2025