%0 Journal Article
%A Conticchio, Maria
%A Delvecchio, Antonella
%A Ratti, Francesca
%A Gelli, Maximiliano
%A Anelli, Ferdinando M
%A Laurent, Alexis
%A Vitali, Giulio C
%A Magistri, Paolo
%A Assirati, Giacomo
%A Felli, Emanuele
%A Wakabayashi, Taiga
%A Pessaux, Patrick
%A Piardi, Tullio
%A Di Benedetto, Fabrizio
%A de'Angelis, Nicola
%A Javier Briceno, Delgado F
%A Rampoldi, Antonio G
%A Adam, René
%A Cherqui, Daniel
%A Aldrighetti, Luca
%A Memeo, Riccardo
%T Laparoscopic surgery versus radiofrequency ablation for the treatment of single hepatocellular carcinoma ≤3 cm in the elderly: a propensity score matching analysis.
%D 2021
%U http://hdl.handle.net/10668/22255
%X Laparoscopic liver resection (LLR) and radiofrequency ablation (RFA) represented potential treatments for patients with a single hepatocellular carcinoma (HCC) smaller than 3 cm. As the aging population soared, our study aimed to examine the advantage/drawback balance for these treatments, which should be reassessed in elderly patients. A multicentric retrospective study compared 184 elderly patients (aged >70 years) (86 patients underwent LLR and 98 had RFA) with single ≤3 cm HCC, observed from January 2009 to January 2019. After propensity score matching (PSM), the estimated 1- and 3-year overall survival rates were 96.5 and 87.9% for the LLR group, and 94.6 and 68.1% for the RFA group (p = 0.001) respectively. The estimated 1- and 3-year disease-free survival rates were 92.5 and 67.4% for the LLR group, and 68.5 and 36.9% for the RFA group (p = 0.001). Patients with HCC of anterolateral segments were more often treated with laparoscopic resection (47 vs. 36, p = 0.04). The median operative time in the resection group was 205 min and 25 min in the RFA group (p = 0.01). Length of hospital stay was 5 days in the resection group and 3 days in the RFA group (p = 0.03). Despite a longer length of hospital stay and operative time, LLR guarantees a comparable postoperative course and a better overall and disease-free survival in elderly patients with single HCC (≤3 cm), located in anterolateral segments.
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