RT Journal Article
T1 Non-invasive ventilation for SARS-CoV-2 acute respiratory failure: a subanalysis from the HOPE COVID-19 registry.
A1 Bertaina, Maurizio
A1 Nuñez-Gil, Ivan J
A1 Franchin, Luca
A1 Fernández Rozas, Inmaculada
A1 Arroyo-Espliguero, Ramón
A1 Viana-Llamas, María C
A1 Romero, Rodolfo
A1 Maroun Eid, Charbel
A1 Uribarri, Aitor
A1 Becerra-Muñoz, Víctor Manuel
A1 Huang, Jia
A1 Alfonso, Emilio
A1 Marmol-Mosquera, Fernando
A1 Ugo, Fabrizio
A1 Cerrato, Enrico
A1 Fernandez-Presa, Lucia
A1 Raposeiras Roubin, Sergio
A1 Feltes Guzman, Gisela
A1 Gonzalez, Adelina
A1 Abumayyaleh, Mohammad
A1 Fernandez-Ortiz, Antonio
A1 Macaya, Carlos
A1 Estrada, Vicente
A1 HOPE COVID-19 investigators, 
K1 COVID-19
K1 acute care
K1 non-invasive
K1 respiratory
K1 ventilation
AB The COVID-19 pandemic has seriously challenged worldwide healthcare systems and limited intensive care facilities, leading to physicians considering the use of non-invasive ventilation (NIV) for managing SARS-CoV-2-related acute respiratory failure (ARF). We conducted an interim analysis of the international, multicentre HOPE COVID-19 registry including patients admitted for a confirmed or highly suspected SARS-CoV-2 infection until 18 April 2020. Those treated with NIV were considered. The primary endpoint was a composite of death or need for intubation. The components of the composite endpoint were the secondary outcomes. Unadjusted and adjusted predictors of the primary endpoint within those initially treated with NIV were investigated. 1933 patients who were included in the registry during the study period had data on oxygen support type. Among them, 390 patients (20%) were treated with NIV. Compared with those receiving other non-invasive oxygen strategy, patients receiving NIV showed significantly worse clinical and laboratory signs of ARF at presentation. Of the 390 patients treated with NIV, 173 patients (44.4%) met the composite endpoint. In-hospital death was the main determinant (147, 37.7%), while 62 patients (15.9%) needed invasive ventilation. Those requiring invasive ventilation had the lowest survival rate (41.9%). After adjustment, age (adjusted OR (adj(OR)) for 5-year increase: 1.37, 95% CI 1.15 to 1.63, p NIV was used in a significant proportion of patients within our cohort, and more than half of these patients survived without the need for intubation. NIV may represent a viable strategy particularly in case of overcrowded and limited intensive care resources, but prompt identification of failure is mandatory to avoid harm. Further studies are required to better clarify our hypothesis. NCT04334291/EUPAS34399.
YR 2021
FD 2021-03-16
LK http://hdl.handle.net/10668/17357
UL http://hdl.handle.net/10668/17357
LA en
DS RISalud
RD Apr 10, 2025