RT Journal Article
T1 The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria.
A1 Porras-Alcala, Cristina
A1 Moya-Utrera, Federico
A1 Garcia-Castro, Miguel
A1 Sanchez-Ruiz, Antonio
A1 Lopez-Romero, Juan Manuel
A1 Pino-Gonzalez, Maria Soledad
A1 Diaz-Morilla, Amelia
A1 Kitamura, Seiya
A1 Wolan, Dennis W
A1 Prados, Jose
A1 Melguizo, Consolacion
A1 Cheng-Sanchez, Ivan
A1 Sarabia, Francisco
K1 SAR
K1 antibiotics
K1 antitumor agents
K1 bengamides
K1 drug-resistant bacteria
AB The bengamides comprise an interesting family of natural products isolated from sponges belonging to the prolific Jaspidae family. Their outstanding antitumor properties, coupled with their unique mechanism of action and unprecedented molecular structures, have prompted an intense research activity directed towards their total syntheses, analogue design, and biological evaluations for their development as new anticancer agents. Together with these biological studies in cancer research, in recent years, the bengamides have been identified as potential antibiotics by their impressive biological activities against various drug-resistant bacteria such as Mycobacterium tuberculosis and Staphylococcus aureus. This review reports on the new advances in the chemistry and biology of the bengamides during the last years, paying special attention to their development as promising new antibiotics. Thus, the evolution of the bengamides from their initial exploration as antitumor agents up to their current status as antibiotics is described in detail, highlighting the manifold value of these marine natural products as valid hits in medicinal chemistry.
PB MDPI AG
YR 2022
FD 2022-05-25
LK http://hdl.handle.net/10668/21417
UL http://hdl.handle.net/10668/21417
LA en
NO Porras-Alcalá C, Moya-Utrera F, García-Castro M, Sánchez-Ruiz A, López-Romero JM, Pino-González MS, et al. The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria. Mar Drugs. 2022 May 31;20(6):373.
DS RISalud
RD Apr 6, 2025