%0 Journal Article
%A Codina, Helena
%A Vieitez, Irene
%A Gutierrez-Valencia, Alicia
%A Skouridou, Vasso
%A Martínez, Cristina
%A Patiño, Lucía
%A Botero-Gallego, Mariluz
%A Trujillo-Rodríguez, María
%A Serna-Gallego, Ana
%A Muñoz-Muela, Esperanza
%A Bobillo, María M
%A Pérez, Alexandre
%A Cabrera-Alvar, Jorge Julio
%A Crespo, Manuel
%A O'Sullivan, Ciara K
%A Ruiz-Mateos, Ezequiel
%A Poveda, Eva
%T Elevated Anti-SARS-CoV-2 Antibodies and IL-6, IL-8, MIP-1β, Early Predictors of Severe COVID-19.
%D 2021
%@ 2076-2607
%U https://hdl.handle.net/10668/24602
%X Viral and host immune kinetics during acute COVID-19 and after remission of acute symptoms need better characterization. SARS-CoV-2 RNA, anti-SARS-CoV-2 IgA, IgM, and IgG antibodies, and proinflammatory cytokines were measured in sequential samples from hospitalized COVID-19 patients during acute infection and six months following diagnosis. Twenty four laboratory confirmed COVID-19 patients with mild/moderate and severe COVID-19 were included. Most were males (83%) with a median age of 61 years. Twenty one percent were admitted to the intensive care unit (ICU) and eight of them (33.3%) met the criteria for severe COVID-19 disease. A delay in SARS-CoV-2 levels' decline during the first six days of follow up, and viral load persistence until month 3 were related to severe COVID-19, but not viral load levels at the diagnosis. Higher levels of anti-SARS-CoV-2 IgA, IgM, IgG and the cytokines IL-6, IL-8 and MIP-1β at the diagnosis time were related to the severe COVID-19 outcome. Higher levels of MIP-1β, IL-1β, MIP-1α and IFN-γ were observed at month 1 and 3 during mild/moderate disease, compared to severe COVID-19. IgG persisted at low levels after six months of diagnosis. In conclusion, higher concentrations of IgA, IgM, and IgG, and IL-6, IL-8 and MIP-1β are identified as early predictors of COVID-19 severity, whereas no significant association is found between baseline SARS-COV-2 viral load and COVID-19 severity.
%K SARS-CoV-2
%K anti-SARS-CoV-2 antibodies
%K cytokines
%K severe COVID-19
%K viral load
%~