RT Journal Article
T1 Seroprevalence and epidemiology of hepatitis B and C viruses in pregnant women in Spain. Risk factors for vertical transmission.
A1 Ruiz-Extremera, Angeles
A1 Diaz-Alcazar, Maria Del Mar
A1 Muñoz-Gamez, Jose Antonio
A1 Cabrera-Lafuente, Marta
A1 Martin, Estefania
A1 Arias-Llorente, Rosa Patricia
A1 Carretero, Pilar
A1 Gallo-Vallejo, Jose Luis
A1 Romero-Narbona, Francisca
A1 Salmeron-Ruiz, M A
A1 Alonso-Diaz, Clara
A1 Maese-Heredia, Rafael
A1 Cerrillos, Lucas
A1 Fernandez-Alonso, Ana Maria
A1 Camarena, Carmen
A1 Aguayo, Josefa
A1 Sanchez-Forte, Miguel
A1 Rodriguez-Maresca, Manuel
A1 Perez-Rivilla, Alfredo
A1 Quiles-Perez, Rosa
A1 Muñoz de Rueda, Paloma
A1 Exposito-Ruiz, Manuela
A1 Garcia, Federico
A1 Garcia, Fernando
A1 Salmeron, Javier
K1 Hepacivirus
K1 Cohort Studies
K1 Pregnancy
K1 Risk Factors
AB Worldwide, measures are being implemented to eradicate hepatitis B (HBV) and C (HCV) viruses, which can be transmitted from the mother during childbirth. This study aims to determine the prevalence of HBV and HCV in pregnant women in Spain, focusing on country of origin, epidemiological factors and risk of vertical transmission (VT). Multicentre open-cohort study performed during 2015. HBV prevalence was determined in 21870 pregnant women and HCV prevalence in 7659 pregnant women. Epidemiological and risk factors for VT were analysed in positive women and differences between HBV and HCV cases were studied. HBV prevalence was 0.42% (91/21870) and HCV prevalence was 0.26% (20/7659). Of the women with HBV, 65.7% (44/67) were migrants. The HBV transmission route to the mother was unknown in 40.3% of cases (27/67) and VT in 31.3% (21/67). Among risk factors for VT, 67.7% (42/62) of the women had viraemia and 14.5% (9/62) tested HBeAg-positive. All of the neonates born to HBV-positive mothers received immunoprophylaxis, and none contracted infection by VT. In 80% (16/20) of the women with HCV, the transmission route was parenteral, and nine were intravenous drug users. Viraemia was present in 40% (8/20) of the women and 10% (2/20) were HIV-coinfected. No children were infected. Women with HCV were less likely than women with HBV to breastfeed their child (65% vs. 86%). The prevalences obtained in our study of pregnant women are lower than those previously documented for the general population. Among the women with HBV, the majority were migrants and had a maternal family history of infection, while among those with HCV, the most common factor was intravenous drug use. Despite the risk factors observed for VT, none of the children were infected. Proper immunoprophylaxis is essential to prevent VT in children born to HBV-positive women.
PB Public Library of Science
YR 2020
FD 2020-05-06
LK http://hdl.handle.net/10668/15608
UL http://hdl.handle.net/10668/15608
LA en
NO Ruiz-Extremera Á, Díaz-Alcázar MDM, Muñoz-Gámez JA, Cabrera-Lafuente M, Martín E, Arias-Llorente RP, et al. Seroprevalence and epidemiology of hepatitis B and C viruses in pregnant women in Spain. Risk factors for vertical transmission. PLoS One. 2020 May 21;15(5):e0233528.
DS RISalud
RD Apr 19, 2025