TY - JOUR AU - Rivera, Patricia AU - Blanco, Eduardo AU - Bindila, Laura AU - Alen, Francisco AU - Vargas, Antonio AU - Rubio, Leticia AU - Pavón, Francisco J AU - Serrano, Antonia AU - Lutz, Beat AU - Rodríguez de Fonseca, Fernando AU - Suárez, Juan PY - 2015 DO - 10.3389/fncel.2015.00379 UR - http://hdl.handle.net/10668/2339 T2 - Frontiers in Cellular Neuroscience AB - Chronic alcohol exposure reduces endocannabinoid activity and disrupts adult neurogenesis in rodents, which results in structural and functional alterations. Cannabinoid receptor agonists promote adult neural progenitor cell (NPC) proliferation. We... LA - en PB - Frontiers Media KW - Alcohol KW - ACEA KW - JWH133 KW - CB1 receptor KW - Neurogenesis KW - CB2 receptor KW - Consumo de alcohol KW - Alcoholismo KW - Benzamidas KW - bromodesoxiuridina KW - Carbamatos KW - Giro dentado KW - Dieta KW - Endocannabinoides KW - Etanol KW - marcadores genéticos KW - Histonas KW - Hidrolasas KW - Hipotálamo KW - Ventrículos laterales KW - Células madre nerviosas KW - Neuronas KW - Fosforilación KW - Ratas KW - Receptor cannabinoide CB1 KW - Sacarosa KW - Tubulina (proteína) KW - Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Drinking Behavior::Alcohol Drinking KW - Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Substance-Related Disorders::Alcohol-Related Disorders::Alcoholism KW - Medical Subject Headings::Organisms::Eukaryota::Animals KW - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Benzamides KW - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleosides::Deoxyribonucleosides::Deoxyuridine::Bromodeoxyuridine KW - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids, Acyclic::Carbamates KW - Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Telencephalon::Cerebrum::Cerebral Cortex::Hippocampus::Dentate Gyrus KW - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Endocannabinoids KW - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Alcohols::Ethanol KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype::Genetic Markers KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nuclear Proteins::Histones KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases KW - Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Diencephalon::Hypothalamus KW - Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Cerebral Ventricles::Lateral Ventricles KW - Medical Subject Headings::Anatomy::Cells::Stem Cells::Neural Stem Cells KW - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Morphogenesis::Embryonic and Fetal Development::Organogenesis::Neurogenesis KW - Medical Subject Headings::Anatomy::Nervous System::Neurons KW - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Phosphorylation KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, G-Protein-Coupled::Receptors, Cannabinoid::Receptor, Cannabinoid, CB1 KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, G-Protein-Coupled::Receptors, Cannabinoid::Receptor, Cannabinoid, CB2 KW - Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Polysaccharides::Oligosaccharides::Disaccharides::Sucrose KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nerve Tissue Proteins::Tubulin KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Cannabinoid Receptor Modulators::Cannabinoid Receptor Agonists TI - Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain. TY - research article ER -