TY  - JOUR
AU  - Giannini, Marta
AU  - Bayona-Feliu, Aleix
AU  - Sproviero, Daisy
AU  - Barroso, Sonia I
AU  - Cereda, Cristina
AU  - Aguilera, Andrés
PY  - 2020
DO  - 10.1371/journal.pgen.1009260
UR  - http://hdl.handle.net/10668/16768
T2  - PLoS genetics
AB  - TDP-43 is a DNA and RNA binding protein involved in RNA processing and with structural resemblance to heterogeneous ribonucleoproteins (hnRNPs), whose depletion sensitizes neurons to double strand DNA breaks (DSBs). Amyotrophic Lateral Sclerosis (ALS)...
LA  - en
KW  - Amyotrophic Lateral Sclerosis
KW  - Animals
KW  - Cells, Cultured
KW  - DNA Breaks, Double-Stranded
KW  - DNA-Binding Proteins
KW  - Genomic Instability
KW  - HeLa Cells
KW  - Homeostasis
KW  - Humans
KW  - Male
KW  - Mice
KW  - Middle Aged
KW  - Mutation
KW  - R-Loop Structures
TI  - TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage.
TY  - research article
VL  - 16
ER  -