RT Journal Article
T1 Predictors of Single Bronchodilation Treatment Response for COPD: An Observational Study with the Trace Database Cohort
A1 Carrasco Hernández, Laura
A1 Caballero Eraso, Candela
A1 Ruiz-Duque, Borja
A1 Abad Arranz, María
A1 Márquez Martín, Eduardo
A1 Calero Acuña, Carmen
A1 Lopez-Campos, Jose Luis
K1 COPD
K1 Long-acting bronchodilators
K1 Clinical response
K1 Pharmacological
K1 Forced expiratory volume
K1 Smoking
K1 Treatment adherence
K1 Exercise
K1 Dyslipidemia
K1 Dyspnea
K1 Enfermedad pulmonar obstructiva crónica
K1 Broncodilatadores
K1 Volumen espiratorio forzado
K1 Fumar
K1 Cumplimiento y adherencia al tratamiento
K1 Ejercicio físico
K1 Dislipidemias
K1 Disnea
AB Chronic obstructive pulmonary disease (COPD) patients constitute a heterogeneous population in terms of treatment response. Our objective was to identify possible predictive factors of response to treatment with single bronchodilation monotherapy in patients diagnosed with COPD. The Time-based Register and Analysis of COPD Endpoints (TRACE; clinicaltrials.gov NCT03485690) is a prospective cohort of COPD patients who have been attending annual visits since 2012. Patients who were kept on a single bronchodilator during the first year of follow-up were selected. The responders were defined according to all of the following variables: any improvement in morning post-dose forced expiratory volume in 1 s or deterioration <100 mL, no change or improvement in dyspnea score, and no occurrence of exacerbations. Significant and plausible variables were analyzed using a proportional hazard Cox regression for single bronchodilator responders. We analyzed 764 cases, of whom 128 (16.8%) were receiving monotherapy with one bronchodilator. Of these, 85 patients (66.4%) were responders. Factors affecting responder status were: female gender (hazard ratio (HR) 0.276; 95% confidence interval (CI) 0.089-0.858), dyslipidemia (HR 0.436; 95%CI 0.202-0.939), not performing regular exercise (HR 0.523; 95%CI 0.254-1.076), active smoking (HR 0.413; 95%CI 0.186-0.920), and treatment adherence (HR 2.527; 95%CI 1.271-5.027). The factors associated with a single bronchodilation response are mainly non-pharmacological interventions and comorbidities.
PB MDPI
YR 2021
FD 2021-04-15
LK http://hdl.handle.net/10668/4332
UL http://hdl.handle.net/10668/4332
LA en
NO Carrasco Hernández L, Caballero Eraso C, Ruiz-Duque B, Abad Arranz M, Márquez Martín E, Calero Acuña C, et al. Predictors of Single Bronchodilation Treatment Response for COPD: An Observational Study with the Trace Database Cohort. J Clin Med. 2021 Apr 15;10(8):1708
DS RISalud
RD Apr 17, 2025