RT Journal Article
T1 COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment.
A1 Moreno-Fernandez, Jorge
A1 Ochoa, Julio J
A1 De Paco Matallana, Catalina
A1 Caño, Africa
A1 Martin-Alvarez, Estefania
A1 Sanchez-Romero, Javier
A1 Toledano, Juan M
A1 Puche-Juarez, Maria
A1 Prados, Sonia
A1 Ruiz-Duran, Susana
A1 Diaz-Meca, Lucia
A1 Carrillo, Maria Paz
A1 Diaz-Castro, Javier
K1 COVID-19
K1 antioxidant system
K1 oxidative stress
K1 placenta
K1 pregnancy
AB COVID-19 has reached pandemic proportions worldwide, with considerable consequences for both health and the economy. In pregnant women, COVID-19 can alter the metabolic environment, iron metabolism, and oxygen supply of trophoblastic cells, and therefore have a negative influence on essential mechanisms of fetal development. The purpose of this study was to investigate, for the first time, the effects of COVID-19 infection during pregnancy with regard to the oxidative/antioxidant status in mothers' serum and placenta, together with placental iron metabolism. Results showed no differences in superoxide dismutase activity and placental antioxidant capacity. However, antioxidant capacity decreased in the serum of infected mothers. Catalase activity decreased in the COVID-19 group, while an increase in 8-hydroxy-2'-deoxyguanosine, hydroperoxides, 15-FT-isoprostanes, and carbonyl groups were recorded in this group. Placental vitamin D, E, and Coenzyme-Q10 also showed to be increased in the COVID-19 group. As for iron-related proteins, an up-regulation of placental DMT1, ferroportin-1, and ferritin expression was recorded in infected women. Due to the potential role of iron metabolism and oxidative stress in placental function and complications, further research is needed to explain the pathogenic mechanism of COVID-19 that may affect pregnancy, so as to assess the short-term and long-term outcomes in mothers' and infants' health.
PB MDPI AG
SN 2076-3921
YR 2022
FD 2022-01-17
LK http://hdl.handle.net/10668/20771
UL http://hdl.handle.net/10668/20771
LA en
NO Moreno-Fernandez J, Ochoa JJ, De Paco Matallana C, Caño A, Martín-Alvarez E, Sanchez-Romero J, et al. COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment. Antioxidants (Basel). 2022 Jan 18;11(2):184.
DS RISalud
RD Apr 7, 2025