RT Journal Article
T1 European intensive care physicians' experience of infections due to antibiotic-resistant bacteria.
A1 Lepape, Alain
A1 Jean, Astrid
A1 De Waele, Jan
A1 Friggeri, Arnaud
A1 Savey, Anne
A1 Vanhems, Philippe
A1 Gustin, Marie Paule
A1 Monnet, Dominique L
A1 Garnacho-Montero, José
A1 Kohlenberg, Anke
K1 Antimicrobial resistance
K1 Antimicrobial treatment
K1 Carbapenem-resistant Enterobacteriaceae
K1 Intensive care
K1 Meticillin-resistant Staphylococcus aureus
K1 Third-generation-cephalosporin-resistant Enterobacteriaceae
AB Antimicrobial resistance (AMR) compromises the treatment of patients with serious infections in intensive care units (ICUs), and intensive care physicians are increasingly facing patients with bacterial infections with limited or no adequate therapeutic options. A survey was conducted to assess the intensive care physicians' perception of the AMR situation in the European Union/European Economic Area (EU/EEA). Between May and July 2017, physicians working in European ICUs were invited to complete an online questionnaire hosted by the European Society of Intensive Care Medicine. The survey included 20 questions on hospital and ICU characteristics, frequency of infections with multidrug-resistant (MDR) bacteria and relevance of AMR in the respondent's ICU, management of antimicrobial treatment as well as the use of last-line antibiotics in the six months preceding the survey. For the analysis of regional differences, EU/EEA countries were grouped into the four sub-regions of Eastern, Northern, Southern and Western Europe. Overall, 1062 responses from four European sub-regions were analysed. Infections with MDR bacteria in their ICU were rated as a major problem by 257 (24.2%), moderate problem by 360 (33.9%) and minor problem by 391 (36.8%) respondents. Third-generation cephalosporin-resistant Enterobacteriaceae were the most frequently encountered MDR bacteria followed by, in order of decreasing frequency, meticillin-resistant Staphylococcus aureus, carbapenem-resistant Enterobacteriaceae, carbapenem-resistant Pseudomonas aeruginosa and vancomycin-resistant enterococci. Perception of the relevance of the AMR problem and the frequency of specific MDR bacteria varied by European sub-region. Bacteria resistant to all or almost all available antibiotics were encountered by 132 (12.4%) respondents. Many physicians reported not having access to specific last-line antibiotics. The percentage of European ICU physicians perceiving AMR as a substantial problem in their ICU is high with variation by sub-region in line with epidemiological studies. The reports of bacteria resistant to almost all available antibiotics and the limited availability of last-line antibiotics in ICUs in the EU/EEA are of concern.
YR 2020
FD 2020-01-02
LK http://hdl.handle.net/10668/14923
UL http://hdl.handle.net/10668/14923
LA en
DS RISalud
RD Apr 8, 2025