RT Journal Article
T1 Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry
A1 Gimeno, Juan R.
A1 Olivotto, Iacopo
A1 Isabel Rodriguez, Ana
A1 Ho, Carolyn Y.
A1 Fernandez, Adrian
A1 Quiroga, Alejandro
A1 Angeles Espinosa, Mari
A1 Gomez-Gonzalez, Cristina
A1 Robledo, Maria
A1 Tojal-Sierra, Lucas
A1 Day, Sharlene M.
A1 Owens, Anjali
A1 Barriales-Villa, Roberto
A1 Maria Larranaga, Jose
A1 Rodriguez-Palomares, Jose
A1 Gonzalez-del-Hoyo, Maribel
A1 Piqueras-Flores, Jesus
A1 Reza, Nosheen
A1 Chumakova, Olga
A1 Ashley, Euan A.
A1 Parikh, Victoria
A1 Wheeler, Matthew
A1 Jacoby, Daniel
A1 Pereira, Alexandre C.
A1 Saberi, Sara
A1 Helms, Adam S.
A1 Villacorta, Eduardo
A1 Gallego-Delgado, Maria
A1 Castro, Daniel
A1 Dominguez, Fernando
A1 Ripoll-Vera, Tomas
A1 Zorio-Grima, Esther
A1 Carlos Sanchez-Martinez, Jose
A1 Garcia-Alvarez, Ana
A1 Arbelo, Elena
A1 Victoria Mogollon, Maria
A1 Eugenia Fuentes-Canamero, Maria
A1 Grande, Elias
A1 Pena, Carlos
A1 Monserrat, Lorenzo
A1 Lakdawala, Neal K.
A1 Dilema Int Cardiomyopathy Heart Fa, 
K1 Hypertrophic cardiomyopathy
K1 COVID-19
K1 SARS-CoV-2 infection
K1 Heart failure
K1 Registry
K1 Prognosis
K1 Classification
K1 Cardiology
K1 Statement
K1 Covid-19
K1 Disease
AB Aims To describe the natural history of SARS-CoV-2 infection in patients with hypertrophic cardiomyopathy (HCM) compared with a control group and to identify predictors of adverse events.Methods and results Three hundred and five patients [age 56.6 +/- 16.9 years old, 191 (62.6%) male patients] with HCM and SARS-Cov-2 infection were enrolled. The control group consisted of 91 131 infected individuals. Endpoints were (i) SARS-CoV-2 related mortality and (ii) severe clinical course [death or intensive care unit (ICU) admission]. New onset of atrial fibrillation, ventricular arrhythmias, shock, stroke, and cardiac arrest were also recorded. Sixty-nine (22.9%) HCM patients were hospitalized for non-ICU level care, and 21 (7.0%) required ICU care. Seventeen (5.6%) died: eight (2.6%) of respiratory failure, four (1.3%) of heart failure, two (0.7%) suddenly, and three (1.0%) due to other SARS-CoV-2-related complications. Covariates associated with mortality in the multivariable were age {odds ratio (OR) per 10 year increase 2.25 [95% confidence interval (CI): 1.12-4.51], P = 0.02291, baseline New York Heart Association class [OR per one-unit increase 4.01 (95%CI: 1.75-9.20), P = 0.0011], presence of left ventricular outflow tract obstruction [OR 5.59 (95%CI: 1.16-26.92), P = 0.0317], and left ventricular systolic impairment [OR 7.72 (95%CI: 1.20-49.79), P = 0.0316]. Controlling for age and sex and comparing HCM patients with a community-based SARS-CoV-2 cohort, the presence of HCM was associated with a borderline significant increased risk of mortality OR 1.70 (95%CI: 0.98-2.91, P = 0.0600).Conclusions Over one-fourth of HCM patients infected with SARS-Cov-2 required hospitalization, including 6% in an ICU setting. Age and cardiac features related to HCM, including baseline functional class, left ventricular outflow tract obstruction, and systolic impairment, conveyed increased risk of mortality.
PB Wiley periodicals, inc
SN 2055-5822
YR 2022
FD 2022-06-03
LK http://hdl.handle.net/10668/21906
UL http://hdl.handle.net/10668/21906
LA en
DS RISalud
RD Apr 8, 2025