%0 Journal Article
%A Gimeno, Juan R.
%A Olivotto, Iacopo
%A Isabel Rodriguez, Ana
%A Ho, Carolyn Y.
%A Fernandez, Adrian
%A Quiroga, Alejandro
%A Angeles Espinosa, Mari
%A Gomez-Gonzalez, Cristina
%A Robledo, Maria
%A Tojal-Sierra, Lucas
%A Day, Sharlene M.
%A Owens, Anjali
%A Barriales-Villa, Roberto
%A Maria Larranaga, Jose
%A Rodriguez-Palomares, Jose
%A Gonzalez-del-Hoyo, Maribel
%A Piqueras-Flores, Jesus
%A Reza, Nosheen
%A Chumakova, Olga
%A Ashley, Euan A.
%A Parikh, Victoria
%A Wheeler, Matthew
%A Jacoby, Daniel
%A Pereira, Alexandre C.
%A Saberi, Sara
%A Helms, Adam S.
%A Villacorta, Eduardo
%A Gallego-Delgado, Maria
%A Castro, Daniel
%A Dominguez, Fernando
%A Ripoll-Vera, Tomas
%A Zorio-Grima, Esther
%A Carlos Sanchez-Martinez, Jose
%A Garcia-Alvarez, Ana
%A Arbelo, Elena
%A Victoria Mogollon, Maria
%A Eugenia Fuentes-Canamero, Maria
%A Grande, Elias
%A Pena, Carlos
%A Monserrat, Lorenzo
%A Lakdawala, Neal K.
%A Dilema Int Cardiomyopathy Heart Fa
%T Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry
%D 2022
%@ 2055-5822
%U http://hdl.handle.net/10668/21906
%X Aims To describe the natural history of SARS-CoV-2 infection in patients with hypertrophic cardiomyopathy (HCM) compared with a control group and to identify predictors of adverse events.Methods and results Three hundred and five patients [age 56.6 +/- 16.9 years old, 191 (62.6%) male patients] with HCM and SARS-Cov-2 infection were enrolled. The control group consisted of 91 131 infected individuals. Endpoints were (i) SARS-CoV-2 related mortality and (ii) severe clinical course [death or intensive care unit (ICU) admission]. New onset of atrial fibrillation, ventricular arrhythmias, shock, stroke, and cardiac arrest were also recorded. Sixty-nine (22.9%) HCM patients were hospitalized for non-ICU level care, and 21 (7.0%) required ICU care. Seventeen (5.6%) died: eight (2.6%) of respiratory failure, four (1.3%) of heart failure, two (0.7%) suddenly, and three (1.0%) due to other SARS-CoV-2-related complications. Covariates associated with mortality in the multivariable were age {odds ratio (OR) per 10 year increase 2.25 [95% confidence interval (CI): 1.12-4.51], P = 0.02291, baseline New York Heart Association class [OR per one-unit increase 4.01 (95%CI: 1.75-9.20), P = 0.0011], presence of left ventricular outflow tract obstruction [OR 5.59 (95%CI: 1.16-26.92), P = 0.0317], and left ventricular systolic impairment [OR 7.72 (95%CI: 1.20-49.79), P = 0.0316]. Controlling for age and sex and comparing HCM patients with a community-based SARS-CoV-2 cohort, the presence of HCM was associated with a borderline significant increased risk of mortality OR 1.70 (95%CI: 0.98-2.91, P = 0.0600).Conclusions Over one-fourth of HCM patients infected with SARS-Cov-2 required hospitalization, including 6% in an ICU setting. Age and cardiac features related to HCM, including baseline functional class, left ventricular outflow tract obstruction, and systolic impairment, conveyed increased risk of mortality.
%K Hypertrophic cardiomyopathy
%K COVID-19
%K SARS-CoV-2 infection
%K Heart failure
%K Registry
%K Prognosis
%K Classification
%K Cardiology
%K Statement
%K Covid-19
%K Disease
%~