RT Journal Article
T1 Genetic variants associated with longitudinal changes in brain structure across the lifespan.
A1 Brouwer, Rachel M
A1 Klein, Marieke
A1 Grasby, Katrina L
A1 Schnack, Hugo G
A1 Jahanshad, Neda
A1 Teeuw, Jalmar
A1 Thomopoulos, Sophia I
A1 Sprooten, Emma
A1 Franz, Carol E
A1 Gogtay, Nitin
A1 Kremen, William S
A1 Panizzon, Matthew S
A1 Olde Loohuis, Loes M
A1 Whelan, Christopher D
A1 Aghajani, Moji
A1 Alloza, Clara
A1 Alnæs, Dag
A1 Artiges, Eric
A1 Ayesa-Arriola, Rosa
A1 Barker, Gareth J
A1 Bastin, Mark E
A1 Blok, Elisabet
A1 Bøen, Erlend
A1 Breukelaar, Isabella A
A1 Bright, Joanna K
A1 Buimer, Elizabeth E L
A1 Bülow, Robin
A1 Cannon, Dara M
A1 Ciufolini, Simone
A1 Crossley, Nicolas A
A1 Damatac, Christienne G
A1 Dazzan, Paola
A1 de Mol, Casper L
A1 de Zwarte, Sonja M C
A1 Desrivières, Sylvane
A1 Díaz-Caneja, Covadonga M
A1 Doan, Nhat Trung
A1 Dohm, Katharina
A1 Fröhner, Juliane H
A1 Goltermann, Janik
A1 Grigis, Antoine
A1 Grotegerd, Dominik
A1 Han, Laura K M
A1 Harris, Mathew A
A1 Hartman, Catharina A
A1 Heany, Sarah J
A1 Heindel, Walter
A1 Heslenfeld, Dirk J
A1 Hohmann, Sarah
A1 Ittermann, Bernd
A1 Jansen, Philip R
A1 Janssen, Joost
A1 Jia, Tianye
A1 Jiang, Jiyang
A1 Jockwitz, Christiane
A1 Karali, Temmuz
A1 Keeser, Daniel
A1 Koevoets, Martijn G J C
A1 Lenroot, Rhoshel K
A1 Malchow, Berend
A1 Mandl, René C W
A1 Medel, Vicente
A1 Meinert, Susanne
A1 Morgan, Catherine A
A1 Mühleisen, Thomas W
A1 Nabulsi, Leila
A1 Opel, Nils
A1 de la Foz, Víctor Ortiz-García
A1 Overs, Bronwyn J
A1 Paillère Martinot, Marie-Laure
A1 Redlich, Ronny
A1 Marques, Tiago Reis
A1 Repple, Jonathan
A1 Roberts, Gloria
A1 Roshchupkin, Gennady V
A1 Setiaman, Nikita
A1 Shumskaya, Elena
A1 Stein, Frederike
A1 Sudre, Gustavo
A1 Takahashi, Shun
A1 Thalamuthu, Anbupalam
A1 Tordesillas-Gutiérrez, Diana
A1 van der Lugt, Aad
A1 van Haren, Neeltje E M
A1 Wardlaw, Joanna M
A1 Wen, Wei
A1 Westeneng, Henk-Jan
A1 Wittfeld, Katharina
A1 Zhu, Alyssa H
A1 Zugman, Andre
A1 Armstrong, Nicola J
A1 Bonfiglio, Gaia
A1 Bralten, Janita
A1 Dalvie, Shareefa
A1 Davies, Gail
A1 Di Forti, Marta
A1 Ding, Linda
A1 Donohoe, Gary
A1 Forstner, Andreas J
A1 Gonzalez-Peñas, Javier
A1 Guimaraes, Joao P O F T
A1 Homuth, Georg
A1 Hottenga, Jouke-Jan
A1 Knol, Maria J
A1 Kwok, John B J
A1 Le Hellard, Stephanie
A1 Mather, Karen A
A1 Milaneschi, Yuri
A1 Morris, Derek W
A1 Nöthen, Markus M
A1 Papiol, Sergi
A1 Rietschel, Marcella
A1 Santoro, Marcos L
A1 Steen, Vidar M
A1 Stein, Jason L
A1 Streit, Fabian
A1 Tankard, Rick M
A1 Teumer, Alexander
A1 van 't Ent, Dennis
A1 van der Meer, Dennis
A1 van Eijk, Kristel R
A1 Vassos, Evangelos
A1 Vázquez-Bourgon, Javier
A1 Witt, Stephanie H
A1 IMAGEN Consortium, 
A1 Adams, Hieab H H
A1 Agartz, Ingrid
A1 Ames, David
A1 Amunts, Katrin
A1 Andreassen, Ole A
A1 Arango, Celso
A1 Banaschewski, Tobias
A1 Baune, Bernhard T
A1 Belangero, Sintia I
A1 Bokde, Arun L W
A1 Boomsma, Dorret I
A1 Bressan, Rodrigo A
A1 Brodaty, Henry
A1 Buitelaar, Jan K
A1 Cahn, Wiepke
A1 Caspers, Svenja
A1 Cichon, Sven
A1 Crespo-Facorro, Benedicto
A1 Cox, Simon R
A1 Dannlowski, Udo
A1 Elvsåshagen, Torbjørn
A1 Espeseth, Thomas
A1 Falkai, Peter G
A1 Fisher, Simon E
A1 Flor, Herta
A1 Fullerton, Janice M
A1 Garavan, Hugh
A1 Gowland, Penny A
A1 Grabe, Hans J
A1 Hahn, Tim
A1 Heinz, Andreas
A1 Hillegers, Manon
A1 Hoare, Jacqueline
A1 Hoekstra, Pieter J
A1 Ikram, Mohammad A
A1 Jackowski, Andrea P
A1 Jansen, Andreas
A1 Jönsson, Erik G
A1 Kahn, Rene S
A1 Kircher, Tilo
A1 Korgaonkar, Mayuresh S
A1 Krug, Axel
A1 Lemaitre, Herve
A1 Malt, Ulrik F
A1 Martinot, Jean-Luc
A1 McDonald, Colm
A1 Mitchell, Philip B
A1 Muetzel, Ryan L
A1 Murray, Robin M
A1 Nees, Frauke
A1 Nenadić, Igor
A1 Oosterlaan, Jaap
A1 Ophoff, Roel A
A1 Pan, Pedro M
A1 Penninx, Brenda W J H
A1 Poustka, Luise
A1 Sachdev, Perminder S
A1 Salum, Giovanni A
A1 Schofield, Peter R
A1 Schumann, Gunter
A1 Shaw, Philip
A1 Sim, Kang
A1 Smolka, Michael N
A1 Stein, Dan J
A1 Trollor, Julian N
A1 van den Berg, Leonard H
A1 Veldink, Jan H
A1 Walter, Henrik
A1 Westlye, Lars T
A1 Whelan, Robert
A1 White, Tonya
A1 Wright, Margaret J
A1 Medland, Sarah E
A1 Franke, Barbara
A1 Thompson, Paul M
A1 Hulshoff Pol, Hilleke E
AB Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.
YR 2022
FD 2022-04-05
LK http://hdl.handle.net/10668/19576
UL http://hdl.handle.net/10668/19576
LA en
DS RISalud
RD Apr 7, 2025