RT Journal Article
T1 The Role of Circulating Aβ Seeds in the Progression of Cerebral Amyloidosis.
A1 Gamez, Nazaret
A1 Morales, Rodrigo
K1 Alzheimer’s disease
K1 amyloid-beta
K1 neurodegeneration
K1 peripheral tissues
K1 prion
AB While understudied, it is suspected that peripheral Aβ peptides affect Alzheimer's disease (AD)-associated pathological changes in the brain. The peripheral sink hypothesis postulates that the central and peripheral pools of Aβ co-exist in equilibrium. As such, cerebral amyloid levels may be modulated by intervening circulating Aβ. In this commentary, we discuss relevant literature supporting the potential role of peripheral Aβ in exacerbating brain amyloidosis in both humans and mouse models of AD. Moreover, we highlight the need to further understand the mechanisms by which circulating Aβ peptides may reach the brain and contribute to neuropathology. Finally, we discuss the implications of targeting peripheral Aβ as a therapeutic approach in treating AD.
YR 2022
FD 2022-09-15
LK http://hdl.handle.net/10668/20243
UL http://hdl.handle.net/10668/20243
LA en
DS RISalud
RD Apr 8, 2025