RT Journal Article
T1 Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study.
A1 Freisling, Heinz
A1 Viallon, Vivian
A1 Lennon, Hannah
A1 Bagnardi, Vincenzo
A1 Ricci, Cristian
A1 Butterworth, Adam S
A1 Sweeting, Michael
A1 Muller, David
A1 Romieu, Isabelle
A1 Bazelle, Pauline
A1 Kvaskoff, Marina
A1 Arveux, Patrick
A1 Severi, Gianluca
A1 Bamia, Christina
A1 Kühn, Tilman
A1 Kaaks, Rudolf
A1 Bergmann, Manuela
A1 Boeing, Heiner
A1 Tjønneland, Anne
A1 Olsen, Anja
A1 Overvad, Kim
A1 Dahm, Christina C
A1 Menéndez, Virginia
A1 Agudo, Antonio
A1 Sanchez-Perez, Maria-Jose
A1 Amiano, Pilar
A1 Santiuste, Carmen
A1 Gurrea, Aurelio Barricarte
A1 Tong, Tammy Y N
A1 Schmidt, Julie A
A1 Tzoulaki, Ioanna
A1 Tsilidis, Konstantinos K
A1 Ward, Heather
A1 Palli, Domenico
A1 Agnoli, Claudia
A1 Tumino, Rosario
A1 Ricceri, Fulvio
A1 Panico, Salvatore
A1 Picavet, H Susan J
A1 Bakker, Marije
A1 Monninkhof, Evelyn
A1 Nilsson, Peter
A1 Manjer, Jonas
A1 Rolandsson, Olov
A1 Thysell, Elin
A1 Weiderpass, Elisabete
A1 Jenab, Mazda
A1 Riboli, Elio
A1 Vineis, Paolo
A1 Danesh, John
A1 Wareham, Nick J
A1 Gunter, Marc J
A1 Ferrari, Pietro
K1 Cancer
K1 Cancer and cardiometabolic multimorbidity
K1 Cardiovascular disease
K1 Diabetes
K1 Healthy lifestyle
K1 Obesity
K1 Prevention
AB Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely investigated. The aim of this study was to investigate associations between five lifestyle factors and incident multimorbidity of cancer and cardiometabolic diseases. In this prospective cohort study, 291,778 participants (64% women) from seven European countries, mostly aged 43 to 58 years and free of cancer, cardiovascular disease (CVD), and type 2 diabetes (T2D) at recruitment, were included. Incident multimorbidity of cancer and cardiometabolic diseases was defined as developing subsequently two diseases including first cancer at any site, CVD, and T2D in an individual. Multi-state modelling based on Cox regression was used to compute hazard ratios (HR) and 95% confidence intervals (95% CI) of developing cancer, CVD, or T2D, and subsequent transitions to multimorbidity, in relation to body mass index (BMI), smoking status, alcohol intake, physical activity, adherence to the Mediterranean diet, and their combination as a healthy lifestyle index (HLI) score. Cumulative incidence functions (CIFs) were estimated to compute 10-year absolute risks for transitions from healthy to cancer at any site, CVD (both fatal and non-fatal), or T2D, and to subsequent multimorbidity after each of the three NCDs. During a median follow-up of 11 years, 1910 men and 1334 women developed multimorbidity of cancer and cardiometabolic diseases. A higher HLI, reflecting healthy lifestyles, was strongly inversely associated with multimorbidity, with hazard ratios per 3-unit increment of 0.75 (95% CI, 0.71 to 0.81), 0.84 (0.79 to 0.90), and 0.82 (0.77 to 0.88) after cancer, CVD, and T2D, respectively. After T2D, the 10-year absolute risks of multimorbidity were 40% and 25% for men and women, respectively, with unhealthy lifestyle, and 30% and 18% for men and women with healthy lifestyles. Pre-diagnostic healthy lifestyle behaviours were strongly inversely associated with the risk of cancer and cardiometabolic diseases, and with the prognosis of these diseases by reducing risk of multimorbidity.
PB BioMed Central Ltd.
YR 2019
FD 2019-11-26
LK http://hdl.handle.net/10668/14937
UL http://hdl.handle.net/10668/14937
LA en
NO Freisling H, Viallon V, Lennon H, Bagnardi V, Ricci C, Butterworth AS, et al. Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study. BMC Med. 2020 Jan 10;18(1):5.
DS RISalud
RD Apr 13, 2025