RT Journal Article T1 Venous thromboembolism in pediatric patients with acute lymphoblastic leukemia under chemotherapy treatment. Risk factors and usefulness of thromboprophylaxis. Results of LAL-SEHOP-PETHEMA-2013. A1 Ruiz-Llobet, Anna A1 Gassiot, Susanna A1 Sarrate, Edurne A1 Zubicaray, Josune A1 Dapena, José Luis A1 Rives, Susana A1 Sevilla, Julián A1 Menárguez López, Ángela A1 Panesso Romero, Melissa A1 Montoya, Catalina A1 Vagace, José Manuel A1 Molina Hurtado, José Ramón A1 García-Morín, Marina A1 García Abós, Miriam A1 Mendoza Sánchez, María Carmen A1 Lendínez, Francisco A1 Palomo Moraleda, Pilar A1 Tallón, María A1 González, Berta A1 Urrutia, Emilia A1 Serna, José Vicente A1 Peláez Pleguezuelos, Irene A1 Martínez Merino, Marta A1 Ramos Elbal, Eduardo A1 Orellana, Elena A1 Benítez Muñoz, Helga A1 Berrueco, Rubén K1 acute lymphoblastic leukemia K1 children K1 prophylaxis K1 thrombophilia K1 thrombosis AB Symptomatic venous thromboembolism (VTE) is diagnosed in 3%-14% of patients during pediatric acute lymphoblastic leukemia (ALL) therapy. There are well-known risk factors, but the role of others as inherited thrombophilia is still controversial. Prophylaxis with low molecular weight heparin (LMWH) has been described, but its use is not globally accepted. A retrospective multicentric study in ALL patients 1-18 years old following SEHOP-PETHEMA-2013 treatment guideline was performed to evaluate VTE rate, anticoagulant treatment, outcome, risk factors, and safety and usefulness of LMWH administration as primary thromboprophylaxis in children with inherited thrombophilia. A total of 652 patients were included in the study. VTE incidence was 8.7%. Most of the cases occurred during induction therapy associated with central venous catheter. Univariant analysis showed that family history of thrombosis, presence of mediastinal mass, high-risk treatment group, and inherited thrombophilia were statistically significant risk factors. LMWH administration seemed to decrease VTE rate in patients with inherited thrombophilia and those with T-cell ALL phenotype. Most of the VTE cases occurred in patients without inherited thrombophilia, but when it is present, the VTE risk is higher. LMWH administration was useful to decrease VTE in these patients. YR 2022 FD 2022-03-27 LK http://hdl.handle.net/10668/20003 UL http://hdl.handle.net/10668/20003 LA en DS RISalud RD Apr 7, 2025