RT Journal Article
T1 The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control
A1 Manzano-López, Javier
A1 Monje-Casas, Fernando
K1 Cdc14
K1 Phosphatase
K1 Mitotic exit
K1 Genome stability
K1 Nucleolus
K1 Autophagy
K1 Cytokinesis
K1 Proteína quinasa CDC2
K1 Monoéster fosfórico hidrolasas
K1 Inestabilidad genómica
K1 Nucléolo celular
K1 Autofagia
K1 Citocinesis
K1 Puntos de control del ciclo celular
K1 Replicación del ADN
AB The Cdc14 phosphatase is a key regulator of mitosis in the budding yeast Saccharomyces cerevisiae. Cdc14 was initially described as playing an essential role in the control of cell cycle progression by promoting mitotic exit on the basis of its capacity to counteract the activity of the cyclin-dependent kinase Cdc28/Cdk1. A compiling body of evidence, however, has later demonstrated that this phosphatase plays other multiple roles in the regulation of mitosis at different cell cycle stages. Here, we summarize our current knowledge about the pivotal role of Cdc14 in cell cycle control, with a special focus in the most recently uncovered functions of the phosphatase.
PB MDPI
YR 2020
FD 2020-01-21
LK http://hdl.handle.net/10668/3704
UL http://hdl.handle.net/10668/3704
LA en
NO Manzano-López J, Monje-Casas F. The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control. Int J Mol Sci. 2020 Jan 21;21(3):709
DS RISalud
RD Apr 9, 2025