RT Journal Article
T1 Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of the PREDIMED-Plus Trial: Role of Body Mass Index and Sex.
A1 Tresserra-Rimbau, Anna
A1 Castro-Barquero, Sara
A1 Vitelli-Storelli, Facundo
A1 Becerra-Tomas, Nerea
A1 Vazquez-Ruiz, Zenaida
A1 Diaz-Lopez, Andres
A1 Corella, Dolores
A1 Castañer, Olga
A1 Romaguera, Dora
A1 Vioque, Jesus
A1 Alonso-Gomez, Angel Maria
A1 Wärnberg, Julia
A1 Martinez, Jose Alfredo
A1 Serra-Majem, Lluis
A1 Estruch, Ramon
A1 Tinahones, Francisco Jose
A1 Lapetra, Jose
A1 Pinto, Xavier
A1 Tur, Josep Antoni
A1 Lopez-Miranda, Jose
A1 Garcia-Molina, Laura
A1 Delgado-Rodriguez, Miguel
A1 Matia-Martin, Pilar
A1 Daimiel, Lidia
A1 Rubin-Garcia, Maria
A1 Vidal, Josep
A1 Galdon, Alba
A1 Ros, Emilio
A1 Basterra-Gortari, Francisco Javier
A1 Babio, Nancy
A1 Sorli, Jose Vicente
A1 Hernaez, Alvaro
A1 Konieczna, Jadwiga
A1 Notario-Barandiaran, Leyre
A1 Tojal-Sierra, Lucas
A1 Perez-Lopez, Jessica
A1 Abete, Itziar
A1 Alvarez-Perez, Jacqueline
A1 Fernandez-Garcia, Jose Carlos
A1 Santos-Lozano, Jose Manuel
A1 Galera-Cusi, Ana
A1 Julibert, Alicia
A1 Ruiz-Canela, Miguel
A1 Martinez-Lacruz, Raul
A1 Perez-Vega, Karla-Alejandra
A1 Galmes-Panades, Aina Maria
A1 Pastor-Polo, Concepcion
A1 Moreno-Rodriguez, Anai
A1 Gea, Alfredo
A1 Fito, Montserrat
A1 Lamuela-Raventos, Rosa Maria
A1 Salas-Salvado, Jordi
K1 catechins
K1 diet
K1 flavonoids
K1 hydroxybenzoic acids
K1 hydroxycinnamic acids
K1 lignans
K1 obesity
K1 phenolic acids
K1 proanthocyanidins
AB Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syndrome and how these associations depend on BMI and sex. This baseline cross-sectional analysis includes 6633 participants from the PREDIMED-Plus trial. Polyphenol intakes were calculated from food frequency questionnaires (FFQ). Cox regression models with constant time at risk and robust variance estimators were used to estimate the prevalence ratios (PRs) for polyphenol intake and T2D prevalence using the lowest quartile as the reference group. Analyses were stratified by sex and BMI groups (overweight and obese) to evaluate potential effect modification. Catechins, proanthocyanidins, hydroxybenzoic acids, and lignans were inversely associated with T2D. Hydroxycinnamic acids were directly related in men. These associations were different depending on sex and BMI, that is, women and overweight obtained stronger inverse associations.
PB MDPI AG
SN 2076-3921
YR 2019
FD 2019-11-08
LK https://hdl.handle.net/10668/26797
UL https://hdl.handle.net/10668/26797
LA en
NO Tresserra-Rimbau A, Castro-Barquero S, Vitelli-Storelli F, Becerra-Tomas N, Vázquez-Ruiz Z, Díaz-López A, et al. Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of the PREDIMED-Plus Trial: Role of Body Mass Index and Sex. Antioxidants (Basel). 2019 Nov 8;8(11):537.
DS RISalud
RD Sep 24, 2025