TY - JOUR AU - Subko, Karolina AU - Wang, Xinhui AU - Nielsen, Frederik H AU - Isbrandt, Thomas AU - Gotfredsen, Charlotte H AU - Ramos, Maria C AU - Mackenzie, Thomas AU - Vicente, Francisca AU - Genilloud, Olga AU - Frisvad, Jens C AU - Larsen, Thomas O PY - 2021 DO - 10.3389/fmicb.2020.618730 SN - 1664-302X UR - http://hdl.handle.net/10668/17077 T2 - Frontiers in microbiology AB - Asperphenamate is a small peptide natural product that has gained much interest due to its antitumor activity. In the recent years numerous bioactive synthetic asperphenamate analogs have been reported, whereas only a handful of natural analogs either... LA - en KW - NRPS flexibility KW - amino acid incorporation KW - asperphenamate KW - biological activity KW - filamentous fungi KW - mass spectrometry KW - natural product discovery TI - Mass Spectrometry Guided Discovery and Design of Novel Asperphenamate Analogs From Penicillium astrolabium Reveals an Extraordinary NRPS Flexibility. TY - research article VL - 11 ER -