RT Journal Article
T1 Sex Hormone Receptor Expression in Craniopharyngiomas and Association with Tumor Aggressiveness Characteristics.
A1 Martínez-Ortega, Antonio
A1 Flores-Martinez, Álvaro
A1 Venegas-Moreno, Eva
A1 Dios, Elena
A1 Del Can, Diego
A1 Rivas, Eloy
A1 Kaen, Ariel
A1 Cárdenas Ruiz-Valdepeñas, Eugenio
A1 Fajardo, Elena
A1 Roldán, Florinda
A1 González-Rivera, Natividad
A1 Oliva, Rosario
A1 Fernández-Peña, José Ignacio
A1 Soto-Moreno, Alfonso
A1 Cano, David A
K1 craniopharyngiomas
K1 estrogen receptor
K1 immunohistochemistry
K1 progesterone receptor
K1 β-catenin
AB Craniopharyngiomas (CPs) are rare tumors of the sellar and suprasellar regions of embryonic origin. The primary treatment for CPs is surgery but it is often unsuccessful. Although CPs are considered benign tumors, they display a relatively high recurrence rate that might compromise quality of life. Previous studies have reported that CPs express sex hormone receptors, including estrogen and progesterone receptors. Here, we systematically analyzed estrogen receptor α (ERα) and progesterone receptor (PR) expression by immunohistochemistry in a well-characterized series of patients with CP (n = 41) and analyzed their potential association with tumor aggressiveness features. A substantial proportion of CPs displayed a marked expression of PR. However, most CPs expressed low levels of ERα. No major association between PR and ERα expression and clinical aggressiveness features was observed in CPs. Additionally, in our series, β-catenin accumulation was not related to tumor recurrence.
SN 2077-0383
YR 2022
FD 2022-01-05
LK http://hdl.handle.net/10668/21228
UL http://hdl.handle.net/10668/21228
LA en
DS RISalud
RD Apr 7, 2025