RT Journal Article
T1 The Coming Age of Flavonoids in the Treatment of Diabetic Complications.
A1 Caro-Ordieres, Teresa
A1 Marín-Royo, Gema
A1 Opazo-Ríos, Lucas
A1 Jiménez-Castilla, Luna
A1 Moreno, Juan Antonio
A1 Gómez-Guerrero, Carmen
A1 Egido, Jesús
K1 cardiovascular disease
K1 diabetes
K1 diabetic nephropathy
K1 flavonoids
K1 inflammation
K1 microvascular complications
K1 oxidative stress
K1 therapeutics
AB Diabetes mellitus (DM), and its micro and macrovascular complications, is one of the biggest challenges for world public health. Despite overall improvement in prevention, diagnosis and treatment, its incidence is expected to continue increasing over the next years. Nowadays, finding therapies to prevent or retard the progression of diabetic complications remains an unmet need due to the complexity of mechanisms involved, which include inflammation, oxidative stress and angiogenesis, among others. Flavonoids are natural antioxidant compounds that have been shown to possess anti-diabetic properties. Moreover, increasing scientific evidence has demonstrated their potential anti-inflammatory and anti-oxidant effects. Consequently, the use of these compounds as anti-diabetic drugs has generated growing interest, as is reflected in the numerous in vitro and in vivo studies related to this field. Therefore, the aim of this review is to assess the recent pre-clinical and clinical research about the potential effect of flavonoids in the amelioration of diabetic complications. In brief, we provide updated information concerning the discrepancy between the numerous experimental studies supporting the efficacy of flavonoids on diabetic complications and the lack of appropriate and well-designed clinical trials. Due to the well-described beneficial effects on different mechanisms involved in diabetic complications, the excellent tolerability and low cost, future randomized controlled studies with compounds that have adequate bioavailability should be evaluated as add-on therapy on well-established anti-diabetic drugs.
SN 2077-0383
YR 2020
FD 2020-01-27
LK https://hdl.handle.net/10668/28315
UL https://hdl.handle.net/10668/28315
LA en
DS RISalud
RD Apr 6, 2025