RT Journal Article
T1 Elevation of serum ferritin levels for predicting a poor outcome in hospitalized patients with influenza infection.
A1 Lalueza, A
A1 Ayuso, B
A1 Arrieta, E
A1 Trujillo, H
A1 Folgueira, D
A1 Cueto, C
A1 Serrano, A
A1 Laureiro, J
A1 Arévalo-Cañas, C
A1 Castillo, C
A1 Díaz-Pedroche, C
A1 Lumbreras, C
A1 INFLUDOC group, 
K1 Ferritin
K1 Hyperferritinaemia
K1 Influenza
K1 Outcome
K1 Respiratory failure
AB There is increasing evidence that ferritin is a key marker of macrophage activation, but its potential role in influenza infection remains unexplored. Our aim was to assess whether hyperferritinaemia (ferritin ≥500 ng/mL) could be a marker of poor prognosis in hospitalized patients with confirmed influenza A infection. We prospectively recruited all hospitalized adult patients who tested positive for the influenza A rRT-PCR assay performed on respiratory samples in two consecutive influenza periods (2016-17 and 2017-18). Poor outcome was defined as the presence of at least one of the following: respiratory failure, admission to the intensive care unit, or in-hospital mortality. Among 494 patients, 68 (14%) developed poor outcomes; 112 patients (23%) had hyperferritinaemia (39/68, 57% in the poor-outcome group versus 73/426, 17% in the remaining patients, p  Serum ferritin may discriminate a subgroup of patients with influenza infection who have a higher risk of developing a poor outcome.
YR 2020
FD 2020-02-28
LK https://hdl.handle.net/10668/25349
UL https://hdl.handle.net/10668/25349
LA en
DS RISalud
RD Apr 8, 2025