%0 Journal Article
%A Lalueza, A
%A Ayuso, B
%A Arrieta, E
%A Trujillo, H
%A Folgueira, D
%A Cueto, C
%A Serrano, A
%A Laureiro, J
%A Arévalo-Cañas, C
%A Castillo, C
%A Díaz-Pedroche, C
%A Lumbreras, C
%A INFLUDOC group
%T Elevation of serum ferritin levels for predicting a poor outcome in hospitalized patients with influenza infection.
%D 2020
%U https://hdl.handle.net/10668/25349
%X There is increasing evidence that ferritin is a key marker of macrophage activation, but its potential role in influenza infection remains unexplored. Our aim was to assess whether hyperferritinaemia (ferritin ≥500 ng/mL) could be a marker of poor prognosis in hospitalized patients with confirmed influenza A infection. We prospectively recruited all hospitalized adult patients who tested positive for the influenza A rRT-PCR assay performed on respiratory samples in two consecutive influenza periods (2016-17 and 2017-18). Poor outcome was defined as the presence of at least one of the following: respiratory failure, admission to the intensive care unit, or in-hospital mortality. Among 494 patients, 68 (14%) developed poor outcomes; 112 patients (23%) had hyperferritinaemia (39/68, 57% in the poor-outcome group versus 73/426, 17% in the remaining patients, p  Serum ferritin may discriminate a subgroup of patients with influenza infection who have a higher risk of developing a poor outcome.
%K Ferritin
%K Hyperferritinaemia
%K Influenza
%K Outcome
%K Respiratory failure
%~