RT Journal Article
T1 Viscoelastic Biomarkers of Ex Vivo Liver Samples via Torsional Wave Elastography
A1 Faris, Inas H.
A1 Melchor, Juan
A1 Callejas, Antonio
A1 Torres, Jorge
A1 Rus, Guillermo
K1 ShearWave Elastography Imaging
K1 TorsionalWave Elastography
K1 Mechanical biomarkers
K1 Tissue biomarkers
K1 Kelvin–Voigt viscoelasticity
K1 Diagnóstico por Imagen de Elasticidad
K1 Onda S
K1 Sustancias viscoelásticas
AB The clinical ultrasound community demands mechanisms to obtain the viscoelastic biomarkers of soft tissue in order to quantify the tissue condition and to be able to track its consistency. Torsional Wave Elastography (TWE) is an emerging technique proposed for interrogating soft tissue mechanical viscoelastic constants. Torsional waves are a particular configuration of shear waves, which propagate asymmetrically in-depth and are radially transmitted by a disc and received by a ring. This configuration is shown to be particularly efficient in minimizing spurious p-waves components and is sensitive to mechanical constants, especially in cylinder-shaped organs. The objective of this work was to validate (TWE) technique against Shear Wave Elasticity Imaging (SWEI) technique through the determination of shear wave velocity, shear moduli, and viscosity of ex vivo chicken liver samples and tissue mimicking hydrogel phantoms. The results of shear moduli for ex vivo liver tissue vary 1.69-4.0kPa using TWE technique and 1.32-4.48kPa using SWEI technique for a range of frequencies from 200 to 800Hz. Kelvin-Voigt viscoelastic parameters reported values of μ = 1.51kPa and η = 0.54Pa·s using TWE and μ = 1.02kPa and η = 0.63Pa·s using SWEI. Preliminary results show that the proposed technique successfully allows reconstructing shear wave velocity, shear moduli, and viscosity mechanical biomarkers from the propagated torsional wave, establishing a proof of principle and warranting further studies.
PB MDPI
YR 2020
FD 2020-02-19
LK http://hdl.handle.net/10668/3578
UL http://hdl.handle.net/10668/3578
LA en
NO Faris IH, Melchor J, Callejas A, Torres J, Rus G. Viscoelastic Biomarkers of Ex Vivo Liver Samples via Torsional Wave Elastography. Diagnostics. 2020 Feb 19;10(2):111
DS RISalud
RD Apr 9, 2025