RT Journal Article
T1 Metabolomic profiling of human lung tumor tissues - nucleotide metabolism as a candidate for therapeutic interventions and biomarkers.
A1 Moreno, Paula
A1 Jimenez-Jimenez, Carla
A1 Garrido-Rodriguez, Martin
A1 Calderon-Santiago, Monica
A1 Molina, Susana
A1 Lara-Chica, Maribel
A1 Priego-Capote, Feliciano
A1 Salvatierra, Angel
A1 Muñoz, Eduardo
A1 Calzado, Marco A
K1 biomarkers
K1 lung cancer
K1 metabolomics
K1 nucleotides
AB Although metabolomics has attracted considerable attention in the field of lung cancer (LC) detection and management, only a very limited number of works have applied it to tissues. As such, the aim of this study was the thorough analysis of metabolic profiles of relevant LC tissues, including the most important histological subtypes (adenocarcinoma and squamous cell lung carcinoma). Mass spectrometry-based metabolomics, along with genetic expression and histological analyses, were performed as part of this study, the widest to date, to identify metabolic alterations in tumors of the most relevant histological subtypes in lung. A total of 136 lung tissue samples were analyzed and 851 metabolites were identified through metabolomic analysis. Our data show the existence of a clear metabolic alteration not only between tumor vs. nonmalignant tissue in each patient, but also inherently intrinsic changes in both AC and SCC. Significant changes were observed in the most relevant biochemical pathways, and nucleotide metabolism showed an important number of metabolites with high predictive capability values. The present study provides a detailed analysis of the metabolomic changes taking place in relevant biochemical pathways of the most important histological subtypes of LC, which can be used as biomarkers and also to identify novel targets.
PB John Wiley & Sons Ltd.
YR 2018
FD 2018-08-03
LK http://hdl.handle.net/10668/12825
UL http://hdl.handle.net/10668/12825
LA en
NO Moreno P, Jiménez-Jiménez C, Garrido-Rodríguez M, Calderón-Santiago M, Molina S, Lara-Chica M, et al. Metabolomic profiling of human lung tumor tissues - nucleotide metabolism as a candidate for therapeutic interventions and biomarkers. Mol Oncol. 2018 Oct;12(10):1778-1796.
NO This work was supported by Consejería de Salud (Junta de Andalucía; PI-0650-2010 and PI-0246-2013) and MICINN (SAF2016-75228-R) grants. MLC was supported by an FPU fellowship (FPU13/03393) from Ministerio de Educación. We acknowledge Carmen Cabrero-Doncel for her assistance with the article.
DS RISalud
RD Apr 7, 2025