RT Journal Article
T1 Plausible Biological Interactions of Low- and Non-Calorie Sweeteners with the Intestinal Microbiota: An Update of Recent Studies
A1 Plaza-Diaz, Julio
A1 Pastor-Villaescusa, Belén
A1 Rueda-Robles, Ascensión
A1 Abadia-Molina, Francisco
A1 Ruiz-Ojeda, Francisco Javier
K1 Nonnutritive sweeteners
K1 Sweetening agents
K1 Gut microbiota
K1 Edulcorantes no nutritivos
K1 Edulcorantes
K1 Microbioma gastrointestinal
AB Sweeteners that are a hundred thousand times sweeter than sucrose are being consumed as sugar substitutes. The effects of sweeteners on gut microbiota composition have not been completely elucidated yet, and numerous gaps related to the effects of nonnutritive sweeteners (NNS) on health still remain. The NNS aspartame and acesulfame-K do not interact with the colonic microbiota, and, as a result, potentially expected shifts in the gut microbiota are relatively limited, although acesulfame-K intake increases Firmicutes and depletes Akkermansia muciniphila populations. On the other hand, saccharin and sucralose provoke changes in the gut microbiota populations, while no health effects, either positive or negative, have been described; hence, further studies are needed to clarify these observations. Steviol glycosides might directly interact with the intestinal microbiota and need bacteria for their metabolization, thus they could potentially alter the bacterial population. Finally, the effects of polyols, which are sugar alcohols that can reach the colonic microbiota, are not completely understood; polyols have some prebiotics properties, with laxative effects, especially in patients with inflammatory bowel syndrome. In this review, we aimed to update the current evidence about sweeteners' effects on and their plausible biological interactions with the gut microbiota.
PB MDPI
YR 2020
FD 2020-04-21
LK http://hdl.handle.net/10668/3832
UL http://hdl.handle.net/10668/3832
LA en
NO Plaza-Diaz J, Pastor-Villaescusa B, Rueda-Robles A, Abadia-Molina F, Ruiz-Ojeda FJ. Plausible Biological Interactions of Low- and Non-Calorie Sweeteners with the Intestinal Microbiota: An Update of Recent Studies. Nutrients. 2020 Apr 21;12(4):1153
DS RISalud
RD Apr 7, 2025