RT Journal Article
T1 Nutrient-wide association study of 92 foods and nutrients and breast cancer risk.
A1 Heath, Alicia K
A1 Muller, David C
A1 van den Brandt, Piet A
A1 Papadimitriou, Nikos
A1 Critselis, Elena
A1 Gunter, Marc
A1 Vineis, Paolo
A1 Weiderpass, Elisabete
A1 Fagherazzi, Guy
A1 Boeing, Heiner
A1 Ferrari, Pietro
A1 Olsen, Anja
A1 Tjønneland, Anne
A1 Arveux, Patrick
A1 Boutron-Ruault, Marie-Christine
A1 Mancini, Francesca Romana
A1 Kühn, Tilman
A1 Turzanski-Fortner, Renée
A1 Schulze, Matthias B
A1 Karakatsani, Anna
A1 Thriskos, Paschalis
A1 Trichopoulou, Antonia
A1 Masala, Giovanna
A1 Contiero, Paolo
A1 Ricceri, Fulvio
A1 Panico, Salvatore
A1 Bueno-de-Mesquita, Bas
A1 Bakker, Marije F
A1 van Gils, Carla H
A1 Olsen, Karina Standahl
A1 Skeie, Guri
A1 Lasheras, Cristina
A1 Agudo, Antonio
A1 Rodríguez-Barranco, Miguel
A1 Sanchez-Perez, Maria-Jose
A1 Amiano, Pilar
A1 Chirlaque, María-Dolores
A1 Barricarte, Aurelio
A1 Drake, Isabel
A1 Ericson, Ulrika
A1 Johansson, Ingegerd
A1 Winkvist, Anna
A1 Key, Tim
A1 Freisling, Heinz
A1 His, Mathilde
A1 Huybrechts, Inge
A1 Christakoudi, Sofia
A1 Ellingjord-Dale, Merete
A1 Riboli, Elio
A1 Tsilidis, Konstantinos K
A1 Tzoulaki, Ioanna
K1 Alcohol
K1 Breast cancer
K1 Diet
K1 Fibre
K1 Foods
K1 Nutrients
AB Several dietary factors have been reported to be associated with risk of breast cancer, but to date, unequivocal evidence only exists for alcohol consumption. We sought to systematically assess the association between intake of 92 foods and nutrients and breast cancer risk using a nutrient-wide association study. Using data from 272,098 women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we assessed dietary intake of 92 foods and nutrients estimated by dietary questionnaires. Cox regression was used to quantify the association between each food/nutrient and risk of breast cancer. A false discovery rate (FDR) of 0.05 was used to select the set of foods and nutrients to be replicated in the independent Netherlands Cohort Study (NLCS). Six foods and nutrients were identified as associated with risk of breast cancer in the EPIC study (10,979 cases). Higher intake of alcohol overall was associated with a higher risk of breast cancer (hazard ratio (HR) for a 1 SD increment in intake = 1.05, 95% CI 1.03-1.07), as was beer/cider intake and wine intake (HRs per 1 SD increment = 1.05, 95% CI 1.03-1.06 and 1.04, 95% CI 1.02-1.06, respectively), whereas higher intakes of fibre, apple/pear, and carbohydrates were associated with a lower risk of breast cancer (HRs per 1 SD increment = 0.96, 95% CI 0.94-0.98; 0.96, 95% CI 0.94-0.99; and 0.96, 95% CI 0.95-0.98, respectively). When evaluated in the NLCS (2368 cases), estimates for each of these foods and nutrients were similar in magnitude and direction, with the exception of beer/cider intake, which was not associated with risk in the NLCS. Our findings confirm a positive association of alcohol consumption and suggest an inverse association of dietary fibre and possibly fruit intake with breast cancer risk.
PB BioMed Central Ltd.
YR 2019
FD 2019-12-30
LK http://hdl.handle.net/10668/14950
UL http://hdl.handle.net/10668/14950
LA en
NO Heath AK, Muller DC, van den Brandt PA, Papadimitriou N, Critselis E, Gunter M, et al. Nutrient-wide association study of 92 foods and nutrients and breast cancer risk. Breast Cancer Res. 2020 Jan 13;22(1):5. doi: 10.1186/s13058-019-1244-7.
DS RISalud
RD Oct 2, 2025