RT Journal Article
T1 SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity.
A1 Seoane-Collazo, Patricia
A1 Roa, Juan
A1 Rial-Pensado, Eva
A1 Liñares-Pose, Laura
A1 Beiroa, Daniel
A1 Ruiz-Pino, Francisco
A1 Lopez-Gonzalez, Tania
A1 Morgan, Donald A
A1 Pardavila, Jose Angel
A1 Sanchez-Tapia, Maria Jesus
A1 Martinez-Sanchez, Noelia
A1 Contreras, Cristina
A1 Fidalgo, Miguel
A1 Dieguez, Carlos
A1 Coppari, Roberto
A1 Rahmouni, Kamal
A1 Nogueiras, Ruben
A1 Tena-Sempere, Manuel
A1 Lopez, Miguel
K1 AMP-activated protein kinases
K1 Adipose tissue, brown
K1 Animals
K1 Body composition
K1 Diet, high-fat
AB AMPK is a cellular gauge that is activated under conditions of low energy, increasing energy production and reducing energy waste. Current evidence links hypothalamic AMPK with the central regulation of energy balance. However, it is unclear whether targeting hypothalamic AMPK has beneficial effects in obesity. Here, we show that genetic inhibition of AMPK in the ventromedial nucleus of the hypothalamus (VMH) protects against high-fat diet (HFD)-induced obesity by increasing brown adipose tissue (BAT) thermogenesis and subsequently energy expenditure. Notably, this effect depends upon the AMPKα1 isoform in steroidogenic factor 1 (SF1) neurons of the VMH, since mice bearing selective ablation of AMPKα1 in SF1 neurons display resistance to diet-induced obesity, increased BAT thermogenesis, browning of white adipose tissue, and improved glucose and lipid homeostasis. Overall, our findings point to hypothalamic AMPK in specific neuronal populations as a potential druggable target for the treatment of obesity and associated metabolic disorders.
PB American Diabetes Association
YR 2018
FD 2018-07-27
LK http://hdl.handle.net/10668/12830
UL http://hdl.handle.net/10668/12830
LA en
NO Seoane-Collazo P, Roa J, Rial-Pensado E, Liñares-Pose L, Beiroa D, Ruíz-Pino F, et al. SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity. Diabetes. 2018 Nov;67(11):2213-2226
DS RISalud
RD Apr 7, 2025