RT Journal Article
T1 Long-term visual pathway alterations after elemental mercury poisoning: report of a series of 29 cases
A1 Pastor-Idoate, Salvador
A1 Coco-Martin, Rosa M.
A1 Zabalza, Iratxe
A1 Lantigua, Yrbani
A1 Fernandez, Itziar
A1 Perez-Castrillon, Jose L.
A1 Cuadrado, Ruben
A1 de Lazaro, Jose A.
A1 Morejon, Angela
A1 Duenas-Laita, Antonio
A1 Pastor, Jose C.
K1 Mercury poisoning
K1 Mercury vapor
K1 Occupational exposure
K1 Optical coherence tomography (OCT)
K1 ocular Electrofisiology
K1 Nerve-fiber layer
K1 Color-vision loss
K1 Full-field
K1 Occupational-exposure
K1 Inorganic mercury
K1 Retinal function
K1 Toxicology
K1 Electroretinography
K1 Impairment
K1 Thickness
AB Background There are few clinical data on retinal involvement after acute exposure to high concentrations mercury and the available reports are based on a small number of patients suffering chronic exposure. The purpose of this paper is to report findings in workers acutely exposed to very high concentrations of mercury vapor with the aim of providing data on a possible direct retinal involvement. Methods Twenty-nine patients and 16 controls were evaluated in a comparative case series. Mercury levels in blood and urine samples, visual acuity (VA), contrast sensitivity (CS), visual field (VF), color discrimination and optical coherence tomography (OCT) were recorded. The pattern reversal visual-evoked potentials (PRVEP), full-field and multifocal electroretinography (ffERG/mfERG), pattern electroretinography (PERG), systemic symptoms, presence of erethism, and electromyography (EMG) were also gathered. A descriptive analysis was performed. The correlations between variables also were studied. In addition, electrophysiological data from those patients with deeper VF defects (group 1) were compared with a normal control group. Results Twenty-six workers exhibited symptoms of erethism. The EMG showed sensorimotor polyneuropathy and multiple mononeuropathy. The VA was slightly affected in 48.27% (n = 14) of subjects. Loss of CS in at least one of four spatial frequencies and color vision alterations occurred in 96.5% (n = 28) and 44.8% (n = 13), respectively. VF alterations were identified in 72.4% (n = 21) patients. No morphologic changes were seen in the OCT scans. Latencies over 100 milliseconds and reduced amplitudes of P100 were found in the PRVEP (p
PB Bmc
SN 1745-6673
YR 2021
FD 2021-11-12
LK https://hdl.handle.net/10668/25210
UL https://hdl.handle.net/10668/25210
LA en
DS RISalud
RD Apr 5, 2025