RT Journal Article
T1 Obesity and menopause modify the epigenomic profile of breast cancer.
A1 Crujeiras, Ana B
A1 Diaz-Lagares, Angel
A1 Stefansson, Olafur A
A1 Macias-Gonzalez, Manuel
A1 Sandoval, Juan
A1 Cueva, Juan
A1 Lopez-Lopez, Rafael
A1 Moran, Sebastian
A1 Jonasson, Jon G
A1 Tryggvadottir, Laufey
A1 Olafsdottir, Elinborg
A1 Tinahones, Francisco J
A1 Carreira, Marcos C
A1 Casanueva, Felipe F
A1 Esteller, Manel
K1 450k methylation array
K1 DNA methylation
K1 breast cancer
K1 epigenomics
K1 obesity
AB Obesity is a high risk factor for breast cancer. This relationship could be marked by a specific methylome. The current work was aimed to explore the impact of obesity and menopausal status on variation in breast cancer methylomes. Data from Infinium 450K array-based methylomes of 64 breast tumors were coupled with information on BMI and menopausal status. Additionally, DNA methylation results were validated in 18 non-tumor and 81 tumor breast samples. Breast tumors arising in either pre- or postmenopausal women stratified by BMI or menopausal status alone were not associated with a specific DNA methylation pattern. Intriguingly, the DNA methylation pattern identified in association with the high-risk group (postmenopausal women with high BMI (>25) and premenopausal women with normal or low BMI 25) and premenopausal women with normal or low BMI 
YR 2017
FD 2017-04-25
LK https://hdl.handle.net/10668/26289
UL https://hdl.handle.net/10668/26289
LA en
DS RISalud
RD Apr 14, 2025