%0 Journal Article
%A Crujeiras, Ana B
%A Diaz-Lagares, Angel
%A Stefansson, Olafur A
%A Macias-Gonzalez, Manuel
%A Sandoval, Juan
%A Cueva, Juan
%A Lopez-Lopez, Rafael
%A Moran, Sebastian
%A Jonasson, Jon G
%A Tryggvadottir, Laufey
%A Olafsdottir, Elinborg
%A Tinahones, Francisco J
%A Carreira, Marcos C
%A Casanueva, Felipe F
%A Esteller, Manel
%T Obesity and menopause modify the epigenomic profile of breast cancer.
%D 2017
%U https://hdl.handle.net/10668/26289
%X Obesity is a high risk factor for breast cancer. This relationship could be marked by a specific methylome. The current work was aimed to explore the impact of obesity and menopausal status on variation in breast cancer methylomes. Data from Infinium 450K array-based methylomes of 64 breast tumors were coupled with information on BMI and menopausal status. Additionally, DNA methylation results were validated in 18 non-tumor and 81 tumor breast samples. Breast tumors arising in either pre- or postmenopausal women stratified by BMI or menopausal status alone were not associated with a specific DNA methylation pattern. Intriguingly, the DNA methylation pattern identified in association with the high-risk group (postmenopausal women with high BMI (>25) and premenopausal women with normal or low BMI 25) and premenopausal women with normal or low BMI 
%K 450k methylation array
%K DNA methylation
%K breast cancer
%K epigenomics
%K obesity
%~