RT Journal Article
T1 Clinical Characteristics and Risk Factors of Respiratory Failure in a Cohort of Young Patients Requiring Hospital Admission with SARS-CoV2 Infection in Spain: Results of the Multicenter SEMI-COVID-19 Registry.
A1 Díaz-Simón, Raquel
A1 Lalueza, Antonio
A1 Lora-Tamayo, Jaime
A1 Rubio-Rivas, Manuel
A1 Mendo, Cristina Llamazares
A1 Martínez, María Luisa Taboada
A1 Méndez, Cristina Asencio
A1 Pesqueira Fontán, Paula M
A1 Cruz, Ana Fernández
A1 Cabrera, Juan Luis Romero
A1 Rodríguez, Begoña Cortés
A1 Rubio, Aurora Espinar
A1 de Ávila, Vicente Serrano Romero
A1 García, Gema Maria García
A1 Osorio, Luis Cabeza
A1 González-Fernández, María
A1 Noya, Amara González
A1 Wittel, Máximo Bernabeu
A1 Fernandez, Francisco Arnalich
A1 Sempere, Verónica Martínez
A1 Artero, Arturo
A1 Loureiro-Amigo, Jose
A1 Huelgas, Ricardo Gómez
A1 Santos, Juan Miguel Antón
A1 Lumbreras, Carlos
A1 SEMI-COVID-19 Network, 
K1 COVID-19
K1 SARS-CoV2
K1 hyponatremia
K1 obesity
K1 respiratory failure
K1 young
AB Age is a risk factor for COVID severity. Most studies performed in hospitalized patients with SARS-CoV2 infection have shown an over-representation of older patients and consequently few have properly defined COVID-19 in younger patients who require hospital admission. The aim of the present study was to analyze the clinical characteristics and risk factors for the development of respiratory failure among young (18 to 50 years) hospitalized patients with COVID-19. This retrospective nationwide cohort study included hospitalized patients from 18 to 50 years old with confirmed COVID-19 between March 1, 2020, and July 2, 2020. All patient data were obtained from the SEMI-COVID Registry. Respiratory failure was defined as the ratio of partial pressure of arterial oxygen to fraction of inspired oxygen (PaO2/FiO2 ratio) ≤200 mmHg or the need for mechanical ventilation and/or high-flow nasal cannula or the presence of acute respiratory distress syndrome. During the recruitment period, 15,034 patients were included in the SEMI-COVID-19 Registry, of whom 2327 (15.4%) were younger than 50 years. Respiratory failure developed in 343 (14.7%), while mortality occurred in 2.3%. Patients with respiratory failure showed a higher incidence of major adverse cardiac events (44 (13%) vs 14 (0.8%), p320 U/I (OR, 1.69; 95% CI, 1.18 to 2.42; p=0.0039), AST >35 mg/dL (OR, 1.74; 95% CI, 1.2 to 2.52; p=0.003), sodium 35 mg/dL (OR, 1.74; 95% CI, 1.2 to 2.52; p=0.003), sodium 8 mg/dL (OR, 2.42; 95% CI, 1.72 to 3.41; p Young patients with COVID-19 requiring hospital admission showed a notable incidence of respiratory failure. Obesity, SAHS, alcohol abuse, and certain laboratory parameters were independently associated with the development of this complication. Patients who suffered respiratory failure had a higher mortality and a higher incidence of major cardiac events, venous thrombosis, and hospital stay.
YR 2021
FD 2021-08-11
LK https://hdl.handle.net/10668/26781
UL https://hdl.handle.net/10668/26781
LA en
DS RISalud
RD Feb 23, 2025