RT Journal Article
T1 Relationship between damage and mortality in juvenile-onset systemic lupus erythematosus: Cluster analyses in a large cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER).
A1 Torrente-Segarra, V
A1 Salman Monte, T C
A1 Rúa-Figueroa, I
A1 De Uña-Álvarez, J
A1 Balboa-Barreiro, V
A1 López-Longo, F J
A1 Galindo-Izquierdo, M
A1 Calvo-Alén, J
A1 Olivé-Marqués, A
A1 Mouriño-Rodríguez, C
A1 Horcada, L
A1 Sánchez-Atrio, A
A1 Montilla, C
A1 Salgado, E
A1 Díez-Álvarez, E
A1 Blanco, R
A1 Andreu, J L
A1 Fernández-Berrizbeitia, O
A1 Hernández-Beriain, J A
A1 Gantes, M
A1 Hernández-Cruz, B
A1 Pecondón-Español, A
A1 Marras, C
A1 Bonilla, G
A1 Pego-Reigosa, J M
A1 RELESSER Study Group of the Spanish Society of Rheumatology (SER) and the Study Group of Systemic Autoimmune Diseases of the SER (EAS-SER), 
K1 Cluster analysis
K1 Juvenile Systemic Lupus Erythematosus
K1 Organ damage, Mortality
K1 RELESSER
AB To identify patterns (clusters) of damage manifestation within a large cohort of juvenile SLE (jSLE) patients and evaluate their possible association with mortality. This is a multicentre, descriptive, cross-sectional study of a cohort of 345 jSLE patients from the Spanish Society of Rheumatology Lupus Registry. Organ damage was ascertained using the Systemic Lupus International Collaborating Clinics Damage Index. Using cluster analysis, groups of patients with similar patterns of damage manifestation were identified and compared. Mean age (years) ± S.D. at diagnosis was 14.2 ± 2.89; 88.7% were female and 93.4% were Caucasian. Mean SLICC/ACR DI ± S.D. was 1.27 ± 1.63. A total of 12 (3.5%) patients died. Three damage clusters were identified: Cluster 1 (72.7% of patients) presented a lower number of individuals with damage (22.3% vs. 100% in Clusters 2 and 3, P  In a large cohort of jSLE patients, renal and musculoskeletal damage manifestations were the two dominant forms of damage by which patients were sorted into clinically meaningful clusters. We found two clusters of jSLE with important clinical damage that were associated with higher rates of mortality, especially for the cluster of patients with predominant renal damage. Physicians should be particularly vigilant to the early prevention of damage in this subset of jSLE patients with kidney involvement.
YR 2018
FD 2018-09-27
LK http://hdl.handle.net/10668/13112
UL http://hdl.handle.net/10668/13112
LA en
DS RISalud
RD Apr 17, 2025