RT Journal Article
T1 Surgical menopause increases salt sensitivity of blood pressure
A1 Hernández Schulman, Ivonne
A1 Aranda, Pedro
A1 Raij, Leopoldo
A1 Veronesi, Maddalena
A1 Aranda, Francisco J.
A1 Martín, Remedios
K1 Risk factors
K1 Hormones
K1 Gender
K1 Cardiovascular diseases
K1 Factores de Riesgo
K1 Hormonas
K1 Género
K1 Enfermedades Cardiovasculares
AB Salt sensitivity of blood pressure is associated with an elevated risk of developing hypertension (HTN) and is an independent risk factor for cardiovascular disease. The prevalence of HTN increases after menopause. The aim of this study was to investigate prospectively whether the loss of ovarian hormones increases the occurrence of salt sensitivity among healthy premenopausal women. We enrolled 40 normotensive, nondiabetic women (age 47.2+/-3.5), undergoing hysterectomy-oophorectomy for nonneoplastic processes and not on hormone replacement, to determine the effect of changes in sodium intake on blood pressure the day before and subsequently 4 months after surgical menopause. Salt loading was achieved using a 2-L normal saline infusion and salt depletion produced by 40 mg of intravenous furosemide. A decrease >10 mm Hg in systolic blood pressure between salt loading and salt depletion was used to define salt sensitivity. Before and after menopause, salt-sensitive women exhibited higher waist/hip and waist/thigh ratios (P<0.01). Although all of the women remained normotensive, the prevalence of salt sensitivity was significantly higher after surgical menopause (21 women; 52.5%) than before (9 women; 22.5%; P=0.01), because 12 (38.7%) salt-resistant women developed salt sensitivity after menopause. In summary, we demonstrated that the prevalence of salt sensitivity doubled as early as 4 months after surgical menopause, without an associated increase in blood pressure. Epidemiological studies indicate that development of HTN may not occur until 5 to 10 years after menopause. The loss of ovarian hormones may unmask a population of women prone to salt sensitivity who, with aging, would be at higher risk for the subsequent development of HTN and cardiovascular disease.
PB Lippincott, Williams & Wilkins
SN 0194-911X
YR 2006
FD 2006-06
LK http://hdl.handle.net/10668/544
UL http://hdl.handle.net/10668/544
LA en
NO Hernández Schulman I, Aranda P, Raij L, Veronesi M, Aranda FJ, Martin R. Surgical menopause increases salt sensitivity of blood pressure. Hypertension. 2006 Jun; 2006;47(6):1168-74
NO Journal Article; Research Support, U.S. Gov't, Non-P.H.S.;
DS RISalud
RD Aug 5, 2025