RT Journal Article
T1 Investigation of gene-environment interactions in relation to tic severity.
A1 Abdulkadir, Mohamed
A1 Yu, Dongmei
A1 Osiecki, Lisa
A1 King, Robert A
A1 Fernandez, Thomas V
A1 Brown, Lawrence W
A1 Cheon, Keun-Ah
A1 Coffey, Barbara J
A1 Garcia-Delgar, Blanca
A1 Gilbert, Donald L
A1 Grice, Dorothy E
A1 Hagstrøm, Julie
A1 Hedderly, Tammy
A1 Heyman, Isobel
A1 Hong, Hyun Ju
A1 Huyser, Chaim
A1 Ibanez-Gomez, Laura
A1 Kim, Young Key
A1 Kim, Young-Shin
A1 Koh, Yun-Joo
A1 Kook, Sodahm
A1 Kuperman, Samuel
A1 Leventhal, Bennett
A1 Madruga-Garrido, Marcos
A1 Maras, Athanasios
A1 Mir, Pablo
A1 Morer, Astrid
A1 Münchau, Alexander
A1 Plessen, Kerstin J
A1 Roessner, Veit
A1 Shin, Eun-Young
A1 Song, Dong-Ho
A1 Song, Jungeun
A1 Visscher, Frank
A1 Zinner, Samuel H
A1 Mathews, Carol A
A1 Scharf, Jeremiah M
A1 Tischfield, Jay A
A1 Heiman, Gary A
A1 Dietrich, Andrea
A1 Hoekstra, Pieter J
K1 Gene–environment interaction
K1 Pre- and perinatal complications
K1 Tic severity
K1 Tourette syndrome
AB Tourette syndrome (TS) is a neuropsychiatric disorder with involvement of genetic and environmental factors. We investigated genetic loci previously implicated in Tourette syndrome and associated disorders in interaction with pre- and perinatal adversity in relation to tic severity using a case-only (N = 518) design. We assessed 98 single-nucleotide polymorphisms (SNPs) selected from (I) top SNPs from genome-wide association studies (GWASs) of TS; (II) top SNPs from GWASs of obsessive-compulsive disorder (OCD), attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD); (III) SNPs previously implicated in candidate-gene studies of TS; (IV) SNPs previously implicated in OCD or ASD; and (V) tagging SNPs in neurotransmitter-related candidate genes. Linear regression models were used to examine the main effects of the SNPs on tic severity, and the interaction effect of these SNPs with a cumulative pre- and perinatal adversity score. Replication was sought for SNPs that met the threshold of significance (after correcting for multiple testing) in a replication sample (N = 678). One SNP (rs7123010), previously implicated in a TS meta-analysis, was significantly related to higher tic severity. We found a gene-environment interaction for rs6539267, another top TS GWAS SNP. These findings were not independently replicated. Our study highlights the future potential of TS GWAS top hits in gene-environment studies.
YR 2021
FD 2021-08-13
LK http://hdl.handle.net/10668/18374
UL http://hdl.handle.net/10668/18374
LA en
DS RISalud
RD Apr 4, 2025