RT Journal Article
T1 Virtual Ontogeny of Cortical Growth Preceding Mental Illness.
A1 Patel, Yash
A1 Shin, Jean
A1 Abé, Christoph
A1 Agartz, Ingrid
A1 Alloza, Clara
A1 Alnæs, Dag
A1 Ambrogi, Sonia
A1 Antonucci, Linda A
A1 Arango, Celso
A1 Arolt, Volker
A1 Auzias, Guillaume
A1 Ayesa-Arriola, Rosa
A1 Banaj, Nerisa
A1 Banaschewski, Tobias
A1 Bandeira, Cibele
A1 Başgöze, Zeynep
A1 Cupertino, Renata Basso
A1 Bau, Claiton H D
A1 Bauer, Jochen
A1 Baumeister, Sarah
A1 Bernardoni, Fabio
A1 Bertolino, Alessandro
A1 Bonnin, Caterina Del Mar
A1 Brandeis, Daniel
A1 Brem, Silvia
A1 Bruggemann, Jason
A1 Bülow, Robin
A1 Bustillo, Juan R
A1 Calderoni, Sara
A1 Calvo, Rosa
A1 Canales-Rodríguez, Erick J
A1 Cannon, Dara M
A1 Carmona, Susanna
A1 Carr, Vaughan J
A1 Catts, Stanley V
A1 Chenji, Sneha
A1 Chew, Qian Hui
A1 Coghill, David
A1 Connolly, Colm G
A1 Conzelmann, Annette
A1 Craven, Alexander R
A1 Crespo-Facorro, Benedicto
A1 Cullen, Kathryn
A1 Dahl, Andreas
A1 Dannlowski, Udo
A1 Davey, Christopher G
A1 Deruelle, Christine
A1 Díaz-Caneja, Covadonga M
A1 Dohm, Katharina
A1 Ehrlich, Stefan
A1 Epstein, Jeffery
A1 Erwin-Grabner, Tracy
A1 Eyler, Lisa T
A1 Fedor, Jennifer
A1 Fitzgerald, Jacqueline
A1 Foran, William
A1 Ford, Judith M
A1 Fortea, Lydia
A1 Fuentes-Claramonte, Paola
A1 Fullerton, Janice
A1 Furlong, Lisa
A1 Gallagher, Louise
A1 Gao, Bingchen
A1 Gao, Si
A1 Goikolea, Jose M
A1 Gotlib, Ian
A1 Goya-Maldonado, Roberto
A1 Grabe, Hans J
A1 Green, Melissa
A1 Grevet, Eugenio H
A1 Groenewold, Nynke A
A1 Grotegerd, Dominik
A1 Gruber, Oliver
A1 Haavik, Jan
A1 Hahn, Tim
A1 Harrison, Ben J
A1 Heindel, Walter
A1 Henskens, Frans
A1 Heslenfeld, Dirk J
A1 Hilland, Eva
A1 Hoekstra, Pieter J
A1 Hohmann, Sarah
A1 Holz, Nathalie
A1 Howells, Fleur M
A1 Ipser, Jonathan C
A1 Jahanshad, Neda
A1 Jakobi, Babette
A1 Jansen, Andreas
A1 Janssen, Joost
A1 Jonassen, Rune
A1 Kaiser, Anna
A1 Kaleda, Vasiliy
A1 Karantonis, James
A1 King, Joseph A
A1 Kircher, Tilo
A1 Kochunov, Peter
A1 Koopowitz, Sheri-Michelle
A1 Landén, Mikael
A1 Landrø, Nils Inge
A1 Lawrie, Stephen
A1 Lebedeva, Irina
A1 Luna, Beatriz
A1 Lundervold, Astri J
A1 MacMaster, Frank P
A1 Maglanoc, Luigi A
A1 Mathalon, Daniel H
A1 McDonald, Colm
A1 McIntosh, Andrew
A1 Meinert, Susanne
A1 Michie, Patricia T
A1 Mitchell, Philip
A1 Moreno-Alcázar, Ana
A1 Mowry, Bryan
A1 Muratori, Filippo
A1 Nabulsi, Leila
A1 Nenadić, Igor
A1 O'Gorman Tuura, Ruth
A1 Oosterlaan, Jaap
A1 Overs, Bronwyn
A1 Pantelis, Christos
A1 Parellada, Mara
A1 Pariente, Jose C
A1 Pauli, Paul
A1 Pergola, Giulio
A1 Piarulli, Francesco Maria
A1 Picon, Felipe
A1 Piras, Fabrizio
A1 Pomarol-Clotet, Edith
A1 Pretus, Clara
A1 Quidé, Yann
A1 Radua, Joaquim
A1 Ramos-Quiroga, J Antoni
A1 Rasser, Paul E
A1 Reif, Andreas
A1 Retico, Alessandra
A1 Roberts, Gloria
A1 Rossell, Susan
A1 Rovaris, Diego Luiz
A1 Rubia, Katya
A1 Sacchet, Matthew
A1 Salavert, Josep
A1 Salvador, Raymond
A1 Sarró, Salvador
A1 Sawa, Akira
A1 Schall, Ulrich
A1 Scott, Rodney
A1 Selvaggi, Pierluigi
A1 Silk, Tim
A1 Sim, Kang
A1 Skoch, Antonin
A1 Spalletta, Gianfranco
A1 Spaniel, Filip
A1 Stein, Dan J
A1 Steinsträter, Olaf
A1 Stolicyn, Aleks
A1 Takayanagi, Yoichiro
A1 Tamm, Leanne
A1 Tavares, Maria
A1 Teumer, Alexander
A1 Thiel, Katharina
A1 Thomopoulos, Sophia I
A1 Tomecek, David
A1 Tomyshev, Alexander S
A1 Tordesillas-Gutiérrez, Diana
A1 Tosetti, Michela
A1 Uhlmann, Anne
A1 Van Rheenen, Tamsyn
A1 Vazquez-Bourgón, Javier
A1 Vernooij, Meike W
A1 Vieta, Eduard
A1 Vilarroya, Oscar
A1 Weickert, Cynthia
A1 Weickert, Thomas
A1 Westlye, Lars T
A1 Whalley, Heather
A1 Willinger, David
A1 Winter, Alexandra
A1 Wittfeld, Katharina
A1 Yang, Tony T
A1 Yoncheva, Yuliya
A1 Zijlmans, Jendé L
A1 Hoogman, Martine
A1 Franke, Barbara
A1 van Rooij, Daan
A1 Buitelaar, Jan
A1 Ching, Christopher R K
A1 Andreassen, Ole A
A1 Pozzi, Elena
A1 Veltman, Dick
A1 Schmaal, Lianne
A1 van Erp, Theo G M
A1 Turner, Jessica
A1 Castellanos, F Xavier
A1 Pausova, Zdenka
A1 Thompson, Paul
A1 Paus, Tomas
K1 Cortical growth
K1 Cortical surface area
K1 Mental illness
K1 Neurodevelopment
K1 Neurogenesis
K1 Psychiatric disorders
AB Morphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental origins mostly undetermined. Deviations in the tangential growth of the cerebral cortex during pre/perinatal periods may be reflected in individual variations in cortical surface area later in life. Interregional profiles of group differences in surface area between cases and controls were generated using T1-weighted magnetic resonance imaging from 27,359 individuals including those with attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia, and high general psychopathology (through the Child Behavior Checklist). Similarity of interregional profiles of group differences in surface area and prenatal cell-specific gene expression was assessed. Across the 11 cortical regions, group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices. The same interregional profiles were also associated with interregional profiles of (prenatal) gene expression specific to proliferative cells, namely radial glia and intermediate progenitor cells (greater expression, larger difference), as well as differentiated cells, namely excitatory neurons and endothelial and mural cells (greater expression, smaller difference). Finally, these cell types were implicated in known pre/perinatal risk factors for psychosis. Genes coexpressed with radial glia were enriched with genes implicated in congenital abnormalities, birth weight, hypoxia, and starvation. Genes coexpressed with endothelial and mural genes were enriched with genes associated with maternal hypertension and preterm birth. Our findings support a neurodevelopmental model of vulnerability to mental illness whereby prenatal risk factors acting through cell-specific processes lead to deviations from typical brain development during pregnancy.
YR 2022
FD 2022-03-04
LK http://hdl.handle.net/10668/22057
UL http://hdl.handle.net/10668/22057
LA en
DS RISalud
RD May 12, 2025