RT Journal Article
T1 EpideMiology and control measures of outBreaks due to Antibiotic-Resistant orGanisms in EurOpe (EMBARGO): a systematic review protocol.
A1 Babu Rajendran, Nithya
A1 Gladstone, Beryl Primrose
A1 Rodríguez-Baño, Jesús
A1 Sifakis, Frangiscos
A1 Voss, Andreas
A1 Carmeli, Yehuda
A1 Burkert, Francesco Robert
A1 Gkolia, Panagiota
A1 Tacconelli, Evelina
K1 Epidemiology
K1 Acinetobacter baumannii
K1 Carbapenémicos
K1 Ceftazidima
K1 Ciprofloxacino
K1 Infección hospitalaria
K1 Brotes de enfermedades
K1 Resistencia a la meticilina
K1 Staphylococcus aureus resistente a meticilina
AB INTRODUCTIONImproving our understanding of outbreaks due to antibiotic-resistant bacteria (ARB) and their control is critical in the current public health scenario. The threat of outbreaks due to ARB requires multifaceted efforts. However, a global overview of epidemiological characteristics of outbreaks due to ARB and effective infection control measures is missing. In this paper, we describe the protocol of a systematic review aimed at mapping and characterising the epidemiological aspects of outbreaks due to ARB and infection control measures in European countries.METHODS AND ANALYSISThe databases MEDLINE, Web of Knowledge and Cochrane library will be searched using a 3-step search strategy. Selection of articles for inclusion will be performed by 2 reviewers using predefined eligibility criteria. All study designs will be included if they report an outbreak and define the microbiological methods used for microorganism identification. The target bacteria will be methicillin-resistant and vancomycin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, ceftazidime-resistant and carbapenem-resistant Acinetobacter baumannii, ceftazidime-resistant and carbapenem-resistant Pseudomonas aeruginosa, ciprofloxacin-resistant Escherichia coli, extended-spectrum β-lactamase-producing E. coli and Klebsiella pneumoniae, carbapenem-resistant and carbapenamase-producing Enterobacteriaceae. Data will be extracted using a tailored pilot tested form and the quality of reporting will be assessed using the ORION (Outbreak Reports and Intervention Studies Of Nosocomial infections) tool. Data will be synthesised and reported by the type of ARB, setting and country. Infection control measures and bundles of measures will be described. The effectiveness will be reported as defined by the authors. Regression analysis will be used to define independent factors associated with outbreaks' control. Heterogeneity between studies will be assessed by forest plots and I² statistics.ETHICS AND DISSEMINATIONEthical approval is not applicable for this study. Findings will be disseminated through journal publication and conference presentations and talks.
PB BMJ Publishing Group
YR 2017
FD 2017-01-05
LK http://hdl.handle.net/10668/2586
UL http://hdl.handle.net/10668/2586
LA en
NO Babu Rajendran N, Gladstone BP, Rodríguez-Baño J, Sifakis F, Voss A, Carmeli Y, et al. EpideMiology and control measures of outBreaks due to Antibiotic-Resistant orGanisms in EurOpe (EMBARGO): a systematic review protocol. BMJ Open. 2017; 7(1):e013634
NO Journal Article; Erratum in:BMJ Open. 2017 Jan 27;7(1):e013634corr1
DS RISalud
RD Apr 8, 2025