RT Journal Article
T1 Reproductive and Lifestyle Factors and Circulating sRANKL and OPG Concentrations in Women: Results from the EPIC Cohort.
A1 Sarink, Danja
A1 Yang, Jiaxi
A1 Johnson, Theron
A1 Chang-Claude, Jenny
A1 Overvad, Kim
A1 Olsen, Anja
A1 Tjønneland, Anne
A1 Fournier, Agnès
A1 Mancini, Francesca Romana
A1 Kvaskoff, Marina
A1 Boeing, Heiner
A1 Trichopoulou, Antonia
A1 Karakatsani, Anna
A1 Valanou, Elissavet
A1 Agnoli, Claudia
A1 Sacerdote, Carlotta
A1 Masala, Giovanna
A1 Mattiello, Amalia
A1 Tumino, Rosario
A1 Van Gils, Carla H
A1 Skeie, Guri
A1 Gram, Inger Torhild
A1 Weiderpass, Elisabete
A1 Lujan-Barroso, Leila
A1 Petrova, Dafina
A1 Santiuste, Carmen
A1 Quirós, J Ramón
A1 Barricarte, Aurelio
A1 Amiano, Pilar
A1 Travis, Ruth C
A1 Gunter, Marc
A1 Dossus, Laure
A1 Christakoudi, Sofia
A1 Kaaks, Rudolf
A1 Fortner, Renée Turzanski
AB Except for a documented increase in osteoprotegerin (OPG) concentrations with older age, data on determinants of soluble Receptor Activator of Nuclear Factor κB (sRANKL) and OPG concentrations in women are limited. We evaluated reproductive and lifestyle factors as potential sources of variation in circulating sRANKL and OPG concentrations in pre- and postmenopausal women. This study includes 2,016 controls [n = 1,552 (76%) postmenopausal, n = 757 (38%) using postmenopausal hormone therapy (PMH)] from a breast cancer case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Serum sRANKL was measured using an ELISA and serum OPG using an electrochemiluminescent assay. Generalized linear models were used to evaluate associations between these analytes and reproductive and lifestyle factors. Older age at blood collection was associated with lower sRANKL concentrations in postmenopausal women (Ptrend ≤ 0.03) and higher OPG concentrations in all women (Ptrend ≤ 0.01). Longer duration of oral contraceptive use among premenopausal women and postmenopausal PMH users was associated with higher OPG (Ptrend ≤ 0.04). In postmenopausal non-PMH users, sRANKL concentrations were lower with longer duration of oral contraceptive use and current (vs. never) smoking (P ≤ 0.01). sRANKL concentrations were higher among women with higher BMI (Ptrend ≤ 0.01). The evaluated factors accounted for 12% of the variation in sRANKL concentrations and 21% of the variation in OPG concentrations. Circulating sRANKL and OPG concentrations are minimally impacted by hormone-related factors in pre- and postmenopausal women. This study suggests circulating concentrations of sRANKL and OPG are unlikely to be strongly modified by hormone-related reproductive and lifestyle factors.
YR 2019
FD 2019-07-10
LK http://hdl.handle.net/10668/14233
UL http://hdl.handle.net/10668/14233
LA en
DS RISalud
RD Apr 18, 2025