%0 Journal Article
%A Santos-Martínez, Sandra
%A Alkhodair, Abdullah
%A Nombela-Franco, Luis
%A Saia, Francesco
%A Muñoz-García, Antonio J
%A Gutiérrez, Enrique
%A Regueiro, Ander
%A Jimenez-Diaz, Victor A
%A Rivero, Fernando
%A Romaguera, Rafael
%A Gómez-Herrero, Javier
%A Rodriguez-Gabella, Tania
%A Sathananthan, Janarthanan
%A Gómez Salvador, Itziar
%A Carrasco-Moraleja, Manuel
%A Rodés-Cabau, Josep
%A Webb, John
%A López, Javier
%A San Román, J Alberto
%A Amat-Santos, Ignacio J
%T Transcatheter Aortic Valve Replacement for Residual Lesion of the Aortic Valve Following "Healed" Infective Endocarditis.
%D 2020
%U http://hdl.handle.net/10668/16241
%X This study aimed to evaluate the safety and mid-term efficacy of transcatheter aortic valve replacement (TAVR) in the setting of aortic valve (AV) infective endocarditis (IE) with residual lesion despite successful antibiotic treatment. Patients with AV-IE presenting residual lesion despite successful antibiotic treatment are often rejected for cardiac surgery due to high-risk. The use of TAVR following IE is not recommended. This was a multicenter retrospective study across 10 centers, gathering baseline, in-hospital, and 1-year follow-up characteristics of patients with healed AV-IE treated with TAVR. Matched comparison according to sex, EuroSCORE, chronic kidney disease, left ventricular function, prosthesis type, and valve-in-valve procedure was performed with a cohort of patients free of prior IE treated with TAVR (46 pairs). Among 2,920 patients treated with TAVR, 54 (1.8%) presented with prior AV-IE with residual valvular lesion and healed infection. They had a higher rate of multivalvular disease and greater surgical risk scores. A previous valvular prosthesis was more frequent than a native valve (50% vs. 7.5%; p  TAVR is a safe therapeutic alternative for residual valvular lesion after successfully healed AV-IE. At 1-year follow-up, the risk of IE relapse was low and mortality rate did not differ from TAVR patients free of prior IE, but one-fourth presented with significant aortic regurgitation and >50% required re-admission.
%K TAVR
%K aortic prosthesis
%K high surgical risk
%K infective endocarditis
%~