TY - GEN AU - Villanueva-Paz, Marina AU - Niu, Hao AU - Segovia-Zafra, Antonio AU - Medina-Caliz, Inmaculada AU - Sanabria-Cabrera, Judith AU - Lucena, M. Isabel AU - Andrade, Raul J. AU - Alvarez-Alvarez, Ismael PY - 2021 DO - 10.3390/jcm10225317 UR - https://hdl.handle.net/10668/26977 T2 - Journal of clinical medicine AB - Drug-induced liver injury (DILI) encompasses the unexpected damage that drugs can cause to the liver. DILI may develop in the context of an immunoallergic syndrome with cutaneous manifestations, which are sometimes severe (SCARs). Nevirapine,... LA - en PB - Mdpi KW - drug-induced liver injury KW - severe cutaneous adverse reactions KW - hypersensitivity KW - gaps KW - causality assessment KW - diagnosis KW - management KW - clinical trial KW - immune response KW - Toxic epidermal necrolysis KW - Stevens-johnson syndrome KW - Systemic symptoms dress KW - Induced hypersensitivity reactions KW - Lymphocyte-transformation test KW - Causality assessment methods KW - Clinical-features KW - Idiosyncratic hepatotoxicity KW - Intravenous immunoglobulin KW - Immunomodulating therapies TI - Critical Review of Gaps in the Diagnosis and Management of Drug-Induced Liver Injury Associated with Severe Cutaneous Adverse Reactions TY - review VL - 10 ER -